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Molecules 2017, 22(3), 400; doi:10.3390/molecules22030400

Pentacyclic Triterpene Bioavailability: An Overview of In Vitro and In Vivo Studies

1
Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café, s/n, Ribeirão Preto, São Paulo 14040903, Brazil
2
Institut des Sciences de la Vie, Université Catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium
3
Louvain Drug Research Institute, Université Catholique de Louvain, B-1200 Brussels, Belgium
4
Department of Environmental Research and Innovation, Luxembourg Institute of Science and Technology, L-4422 Belvaux, Luxembourg
*
Authors to whom correspondence should be addressed.
Academic Editor: Nancy D. Turner
Received: 3 February 2017 / Revised: 24 February 2017 / Accepted: 28 February 2017 / Published: 4 March 2017
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [1095 KB, uploaded 4 March 2017]   |  

Abstract

Pentacyclic triterpenes are naturally found in a great variety of fruits, vegetables and medicinal plants and are therefore part of the human diet. The beneficial health effects of edible and medicinal plants have partly been associated with their triterpene content, but the in vivo efficacy in humans depends on many factors, including absorption and metabolism. This review presents an overview of in vitro and in vivo studies that were carried out to determine the bioavailability of pentacyclic triterpenes and highlights the efforts that have been performed to improve the dissolution properties and absorption of these compounds. As plant matrices play a critical role in triterpene bioaccessibility, this review covers literature data on the bioavailability of pentacyclic triterpenes ingested either from foods and medicinal plants or in their free form. View Full-Text
Keywords: pentacyclic triterpenes; bioavailability; in vitro studies; in vivo studies pentacyclic triterpenes; bioavailability; in vitro studies; in vivo studies
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MDPI and ACS Style

J. C. Furtado, N.A.; Pirson, L.; Edelberg, H.; M. Miranda, L.; Loira-Pastoriza, C.; Preat, V.; Larondelle, Y.; André, C.M. Pentacyclic Triterpene Bioavailability: An Overview of In Vitro and In Vivo Studies. Molecules 2017, 22, 400.

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