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Molecules 2017, 22(3), 389; doi:10.3390/molecules22030389

New Cytotoxic Seco-Type Triterpene and Labdane-Type Diterpenes from Nuxia oppositifolia

Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, El-Mansoura 35516, Egypt
Department of Pharmacognosy, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-kharj 11942, Saudi Arabia
Department of Pharmacognosy, College of Pharmacy, Alexandria University, Alexandria 21215, Egypt
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 26 January 2017 / Revised: 26 February 2017 / Accepted: 27 February 2017 / Published: 2 March 2017
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [762 KB, uploaded 2 March 2017]   |  


Chromatographic purification of the n-hexane and dichloromethane extracts of Nuxia oppositifolia aerial parts, growing in Saudi Arabia, resulted in the isolation and characterization of three new labdane-type diterpene acids, 2β-acetoxy-labda-7-en-15-oic acid (1), 2β-acetoxy-7-oxolabda-8-en-15-oic acid (2), 2β-acetoxy-6-oxolabda-7-en-15-oic acid (3), and one new seco-triterpene, 3,4-seco olean-12-en-3,30 dioic acid (4), together with 10 known lupane, oleanane and ursane-type triterpenes, as well as the common phytosterols, β-sitosterol and stigmasterol (516). Their structures have been assigned on the basis of different spectroscopic techniques including 1D and 2D NMR. Moreover, 13 of the isolated compounds were tested on the human cancer cell lines HeLa (cervical), A549 (lung) and MDA (breast), and most of the compounds showed potent cytotoxic activities in vitro. View Full-Text
Keywords: Nuxia oppositifolia; labdane-type diterpene; seco-triterpene; triterpenes; cytotoxicity Nuxia oppositifolia; labdane-type diterpene; seco-triterpene; triterpenes; cytotoxicity

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Al-Massarani, S.M.; El-Gamal, A.A.; Parvez, M.K.; Al-Dosari, M.S.; Al-Said, M.S.; Abdel-Kader, M.S.; Basudan, O.A. New Cytotoxic Seco-Type Triterpene and Labdane-Type Diterpenes from Nuxia oppositifolia. Molecules 2017, 22, 389.

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