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Molecules 2017, 22(3), 392; doi:10.3390/molecules22030392

Electrochemical Detecting Lung Cancer-Associated Antigen Based on Graphene-Gold Nanocomposite

1
Department of Oncology, Henan Academy institute of Traditional Chinese Medicine, Zhengzhou 450004, Henan, China
2
Department of Traditional Chinese Medicine, Henan Province People’s Hospital, Zhengzhou 450004, Henan, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 26 January 2017 / Revised: 21 February 2017 / Accepted: 28 February 2017 / Published: 2 March 2017
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Abstract

Using a Au nanoparticle/reduced graphene oxide composite (AuNP-RGO), a signal-enhanced electrochemical immunosensor without label was created to detect neuron-specific enolase (NSE). Furthermore, an environmentally-friendly method was developed to prepare AuNP-RGO by employing chitosan (CS), which served as reducing and stabilizing agent. We showed that the sensitivity of the immunosensor designed in this report was remarkably enhanced because of the numerous active sites in the sensor provided by the AuNP-RGO nanostructure. For the quantification of NSE, the immunosensor exhibited a positive linear relationship with the concentration in the range of 0.1 to 2000 ng/mL, where the limit of the detection was 0.05 ng/mL. View Full-Text
Keywords: label-free immunosensor; neuron-specific enolase (NSE); signal-enhanced; electrochemical immunosensors; graphene label-free immunosensor; neuron-specific enolase (NSE); signal-enhanced; electrochemical immunosensors; graphene
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wei, Z.; Zhang, J.; Zhang, A.; Wang, Y.; Cai, X. Electrochemical Detecting Lung Cancer-Associated Antigen Based on Graphene-Gold Nanocomposite. Molecules 2017, 22, 392.

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