Solvent and Copper Ion-Induced Synthesis of Pyridyl–Pyrazole-3-One Derivatives: Crystal Structure, Cytotoxicity
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis
2.2. Description of the Crystal Structures
2.2.1. Crystal Structures of 1 and 2
2.2.2. Crystal Structure of 3
2.2.3. Crystal Structures of 4 and 5
2.3. In-Vitro Antitumor-Activity Screening by MTT Assay
3. Experimental Section
3.1. Materials and Instrumentation
3.2. Synthesis
3.3. X-ray Crystallography
3.4 Cell Culture and Treatment
3.5. In-Vitro Cytotoxicity MTT Assay
4. Conclusions
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Sample Availability: Samples of the compounds 1–5 are available from the authors. |
Compounds | BEL-7404 | HepG2 | NCI-H460 | T-24 | A549 | HL-7702 |
---|---|---|---|---|---|---|
1 | 66.51 ± 1.13 | 37.15 ± 0.54 | 108.97 ± 1.65 | 70.51 ± 1.33 | 37.56 ± 1.03 | 110.65 ± 2.84 |
2 | 125.20 ± 1.87 | 29.75 ± 0.91 | 40.67 ± 0.54 | 46.21 ± 0.87 | 44.77 ± 1.12 | 118.36 ± 3.34 |
3 | 112.28 ± 2.78 | 54.74 ± 0.81 | 38.03 ± 0.89 | 85.38 ± 0.67 | 33.56 ± 1.07 | 150.83 ± 3.06 |
4 | 41.81 ± 0.37 | 10.66 ± 0.38 | 66.48 ± 0.57 | 42.89 ± 1.41 | 28.09 ± 1.01 | 96.14 ± 0.49 |
5 | 84.26 ± 1.01 | 175.23 ± 1.10 | 94.56 ± 0.41 | 76.03 ± 1.16 | 77.56 ± 0.72 | 102.26 ± 0.85 |
Cisplatin b | 12.41 ± 0.38 | 9.48 ± 0.35 | 18.89 ± 1.02 | 28.07 ± 1.88 | 9.48 ± 0.35 | 5.63 ± 0.32 |
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Huang, Q.P.; Zhang, S.N.; Zhang, S.H.; Wang, K.; Xiao, Y. Solvent and Copper Ion-Induced Synthesis of Pyridyl–Pyrazole-3-One Derivatives: Crystal Structure, Cytotoxicity. Molecules 2017, 22, 1813. https://doi.org/10.3390/molecules22111813
Huang QP, Zhang SN, Zhang SH, Wang K, Xiao Y. Solvent and Copper Ion-Induced Synthesis of Pyridyl–Pyrazole-3-One Derivatives: Crystal Structure, Cytotoxicity. Molecules. 2017; 22(11):1813. https://doi.org/10.3390/molecules22111813
Chicago/Turabian StyleHuang, Qiu Ping, Shao Nan Zhang, Shu Hua Zhang, Kai Wang, and Yu Xiao. 2017. "Solvent and Copper Ion-Induced Synthesis of Pyridyl–Pyrazole-3-One Derivatives: Crystal Structure, Cytotoxicity" Molecules 22, no. 11: 1813. https://doi.org/10.3390/molecules22111813