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Molecules 2017, 22(10), 1665; doi:10.3390/molecules22101665

Synthesis of Chromone-Related Pyrazole Compounds

1
School of Agriculture, Polytechnic Institute of Bragança, 5300-253 Bragança, Portugal
2
Department of Chemistry & QOPNA, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal
*
Author to whom correspondence should be addressed.
Received: 28 August 2017 / Revised: 22 September 2017 / Accepted: 28 September 2017 / Published: 5 October 2017
(This article belongs to the Special Issue Pyrazole Derivatives)

Abstract

Chromones, six-membered oxygen heterocycles, and pyrazoles, five-membered two-adjacentnitrogen- containing heterocycles, represent two important classes of biologically active compounds. Certain derivatives of these scaffolds play an important role in medicinal chemistry and have been extensively used as versatile building blocks in organic synthesis. In this context, we will discuss the most relevant advances on the chemistry that involves both chromone and pyrazole rings. The methods reviewed include the synthesis of chromone-pyrazole dyads, synthesis of chromone-pyrazole-fused compounds, and chromones as starting materials in the synthesis of 3(5)-(2-hydroxyaryl)pyrazoles, among others. This review will cover the literature on the chromone and pyrazole dual chemistry and their outcomes in the 21st century. View Full-Text
Keywords: chromone; dyads; heterocycles; pyrazole; reactivity; review; organic synthesis chromone; dyads; heterocycles; pyrazole; reactivity; review; organic synthesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Santos, C.M.M.; Silva, V.L.M.; Silva, A.M.S. Synthesis of Chromone-Related Pyrazole Compounds. Molecules 2017, 22, 1665.

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