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Molecules 2017, 22(11), 1814; doi:10.3390/molecules22111814

Anticancer Effects of Resveratrol-Loaded Solid Lipid Nanoparticles on Human Breast Cancer Cells

1
Department of Biotechnology, Bengbu Medical College, Anhui, Bengbu 233030, China
2
Clinical Testing and Diagnose Experimental Center, Bengbu Medical College, Anhui, Bengbu 233030, China
3
Department of Biochemistry and Molecular Biology, Bengbu Medical College, Anhui, Bengbu 233030, China
4
Department of Oncology, Bengbu Medical College, Anhui, Bengbu 233030, China
*
Authors to whom correspondence should be addressed.
Received: 16 September 2017 / Accepted: 21 October 2017 / Published: 25 October 2017
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Abstract

In this study, resveratrol-loaded solid lipid nanoparticles (Res-SLNs) were successfully designed to treat MDA-MB-231 cells. The Res-SLNs were prepared using emulsification and low-temperature solidification method. The Res-SLNs were spherical, with small size, negative charge, and narrow size distribution. Compared with free resveratrol, the Res-SLNs displayed a superior ability in inhibiting the proliferation of MDA-MB-231 cells. In addition, Res-SLNs exhibited much stronger inhibitory effects on the invasion and migration of MDA-MB-231 cells. Western blot analysis revealed that Res-SLNs could promote the ratio of Bax/Bcl-2 but decreased the expression of cyclinD1 and c-Myc. These results indicate that the Res-SLN may have great potential for breast cancer treatment. View Full-Text
Keywords: solid lipid nanoparticle; resveratrol; breast cancer; cyclinD1 solid lipid nanoparticle; resveratrol; breast cancer; cyclinD1
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MDPI and ACS Style

Wang, W.; Zhang, L.; Chen, T.; Guo, W.; Bao, X.; Wang, D.; Ren, B.; Wang, H.; Li, Y.; Wang, Y.; Chen, S.; Tang, B.; Yang, Q.; Chen, C. Anticancer Effects of Resveratrol-Loaded Solid Lipid Nanoparticles on Human Breast Cancer Cells. Molecules 2017, 22, 1814.

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