Stereoselective Synthesis of α-Amino-C-phosphinic Acids and Derivatives
Abstract
:1. Introduction
2. Stereoselective Synthesis of Acyclic α-Amino-C-phosphinic Acids and Derivatives
2.1. Stereoselective C-P Bond Formation (Addition of Phosphorus Compounds to Imines)
2.1.1. Chiral Imine Compounds
2.1.2. Chiral Catalyst
2.2. Stereoselective C-P Bond Formation (One-Pot Three-Component Reaction)
2.2.1. Chiral Amino Compounds
2.3. Stereoselective C-H Bond Formation
2.3.1. Reduction of C=C Bond in α,β-Dehydroaminophosphinates
2.4. Resolution Methodologies
2.5. Conversion from Chiral α-Aminophosphonates
2.6. P-C Bond Formation from Chiral α-Amino-H-phosphinic Derivatives
3. Synthesis of Phosphacyclic α-Amino-C-phosphinates
3.1. 1,4,2-Oxazaphosphacycles
3.2. 1,2-Oxaphosphacycles
4. Conclusions
Acknowledgments
Conflicts of Interest
Abbreviations
References
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Viveros-Ceballos, J.L.; Ordóñez, M.; Sayago, F.J.; Cativiela, C. Stereoselective Synthesis of α-Amino-C-phosphinic Acids and Derivatives. Molecules 2016, 21, 1141. https://doi.org/10.3390/molecules21091141
Viveros-Ceballos JL, Ordóñez M, Sayago FJ, Cativiela C. Stereoselective Synthesis of α-Amino-C-phosphinic Acids and Derivatives. Molecules. 2016; 21(9):1141. https://doi.org/10.3390/molecules21091141
Chicago/Turabian StyleViveros-Ceballos, José Luis, Mario Ordóñez, Francisco J. Sayago, and Carlos Cativiela. 2016. "Stereoselective Synthesis of α-Amino-C-phosphinic Acids and Derivatives" Molecules 21, no. 9: 1141. https://doi.org/10.3390/molecules21091141