Arginine: New Insights into Growth Performance and Urinary Metabolomic Profiles of Rats
AbstractArginine regulates growth performance, nutrient metabolism and health effects, but the underlying mechanism remains unknown. This study aims to investigate the effect of dietary arginine supplementation on rat growth performance and urinary metabolome through 1H-NMR spectroscopy. Twenty rats were randomly assigned to two groups supplemented with 0% or 1.0% l-arginine for 4 weeks. Urine samples were analyzed through NMR-based metabolomics. Arginine supplementation significantly increased the urine levels of 4-aminohippurate, acetate, creatine, creatinine, ethanolamine, formate, hippurate, homogentisate, indoxyl sulfate, and phenylacetyglycine. Conversely, arginine decreased the urine levels of acetamide, β-glucose, cirtulline, ethanol, glycine, isobutyrate, lactate, malonate, methymalonate, N-acetylglutamate, N-methylnicotinamide, and propionate. Results suggested that arginine can alter common systemic metabolic processes, including energy metabolism, amino acid metabolism, and gut microbiota metabolism. Moreover, the results also imply a possible physiological role of the metabolism in mediating the arginine supplementation-supported growth of rats. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Liu, G.; Wu, X.; Jia, G.; Chen, X.; Zhao, H.; Wang, J.; Wu, C.; Cai, J. Arginine: New Insights into Growth Performance and Urinary Metabolomic Profiles of Rats. Molecules 2016, 21, 1142.
Liu G, Wu X, Jia G, Chen X, Zhao H, Wang J, Wu C, Cai J. Arginine: New Insights into Growth Performance and Urinary Metabolomic Profiles of Rats. Molecules. 2016; 21(9):1142.Chicago/Turabian Style
Liu, Guangmang; Wu, Xianjian; Jia, Gang; Chen, Xiaoling; Zhao, Hua; Wang, Jing; Wu, Caimei; Cai, Jingyi. 2016. "Arginine: New Insights into Growth Performance and Urinary Metabolomic Profiles of Rats." Molecules 21, no. 9: 1142.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.