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Molecules 2016, 21(8), 1085; doi:10.3390/molecules21081085

Immunomodulatory and Antioxidant Effects of Polysaccharides from Gynostemma pentaphyllum Makino in Immunosuppressed Mice

1
The Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, Shaanxi, China
2
Department of Orthopaedics, The First Affiliated Hospital of Xi’an Medical University, Xi’an 710077, Shaanxi, China
3
Key Laboratory of High Altitude Environment and Related Illness of Tibet Autonomous Region, Department of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Quan-Bin Han, Sunan Wang and Shaoping Nie
Received: 13 July 2016 / Revised: 12 August 2016 / Accepted: 15 August 2016 / Published: 19 August 2016
(This article belongs to the Special Issue Natural Polysaccharides)
View Full-Text   |   Download PDF [1338 KB, uploaded 19 August 2016]   |  

Abstract

The immunomodulatory and antioxidant activities of crude polysaccharides extracted from Gynostemma pentaphyllum Makino (GPMPP) were investigated. GPMPP was composed of rhamnose, arabinose, xylose, mannose, glucose and galactose in the molar ratio of 1.39:3.76:1.00:1.64:4.98:5.88. In vivo studies showed GPMPP significantly increased the spleen and thymus indices, activated the macrophage phagocytosis and NK cells, and exhibited activity on none or Con A/LPS-stimulated splenocytes in a dose-dependent manner in C57BL/6 mice. Moreover, GPMPP elevated CD4+ T lymphocyte counts as well as the CD4+/CD8+ ratio dose-dependently, and it increased IL-2 level in the sera and spleen of Cy-immunosuppressed mice. Furthermore, GPMPP significantly increased the SOD, GSH-Px, T-AOC, GSH and CAT level, and decreased the MDA level. The results showed that GPMPP might play an important role in prevention of oxidative damage in immunological system. These findings indicate GPMPP has immunomodulatory activity in vivo and seems to be an effective natural immunomodulatory agent. View Full-Text
Keywords: Gynostemma pentaphyllum Makino; polysaccharide; in vivo; immunomodulatory; antioxidant Gynostemma pentaphyllum Makino; polysaccharide; in vivo; immunomodulatory; antioxidant
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Shang, X.; Chao, Y.; Zhang, Y.; Lu, C.; Xu, C.; Niu, W. Immunomodulatory and Antioxidant Effects of Polysaccharides from Gynostemma pentaphyllum Makino in Immunosuppressed Mice. Molecules 2016, 21, 1085.

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