Special Issue "Natural Polysaccharides"
Deadline for manuscript submissions: closed (30 April 2017)
Prof. Sunan Wang
Canadian Food and Wine Institute, Niagara College, Niagara-on-the-Lake, Canada
Interests: ingredient technology and value added processing of foods; plant bioactives for chronic disease prevention; food microbiology and food safety
Natural polysaccharides are attracting increasing interests from scientists in multidisciplinary research fields, because they are esculent and show a broad spectrum of bio-activities, including immunoregulatory activity, anti-fatigue activity, antioxidant activity, antitumor activity, anti-diabetic activity, and anti-inflammatory activity.
Water decoction is the most popularly used form of Chinese medicine, in which alcohol-soluble small molecules are always the research focus. However, some of these small molecules do not show any bioactivities associated with the traditional use of the decoction, and some of them do not exist in the decoctions at all. On the other hand, polysaccharides, as the majority of the decoctions, might be responsible for its bioactivities. Hence, exploring the chemistry and bioactivities of polysaccharides will help to uncover the secrets of Chinese Medicine decoctions.
Difficulties are still significant. First of all, the purity concept is different from that of small molecules. Natural polysaccharides are always a mixture. The repeatability of sample preparation is not reliable, so that polysaccharides isolated from the same natural resource hardly show identical structural data. Furthermore, it is not easy to obtain high-resolution 2D-NMR spectra of a purified polysaccharide. In addition to the difficulties in chemical study, our knowledge to the mechanism of polysaccharides’ bioactivities is poor, because all these bioactivities are associated with the immunomodulatory activity to which we have not known much. All the above-mentioned difficulties further limited our knowledge to the structure-activity relationship.
Therefore, any efforts to investigate the extraction, separation, structure elucidation, quality analysis, bioactivities, mechanism of action, and the structure-activity relationship of natural polysaccharides should be encouraged. Review articles are also welcome.
Dr. Quan-Bin Han
Prof. Sunan Wang
Prof. Shaoping Nie
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- extraction methodology
- separation technology
- structure elucidation
- quality analysis
- acute and long-term toxicity
- mechanism of action
- structure-activity relationship