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Molecules 2016, 21(7), 928; doi:10.3390/molecules21070928

Layered Double Hydroxide as a Vehicle to Increase Toxicity of Gallate Ions against Adenocarcinoma Cells

1
Departamento de Ciencias de la Salud, Centro Universitario de Tonalá, Universidad de Guadalajara, Avenida Nuevo Periférico 555, 48525 Tonalá, Jalisco, Mexico
2
Departamento de Bioquímica, Instituto Nacional de Enfermedades Respiratorias, Calzada de Tlalpan 4502, 14080 Mexico City, Mexico
3
Departamento de Química, Universidad de Guadalajara, Marcelino García Barragán 1421, 44430 Guadalajara, Jalisco, Mexico
4
Departamento de Farmacobiología, Universidad de Guadalajara, Marcelino García Barragán 1421, 44430 Guadalajara, Jalisco, Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Didier Astruc
Received: 14 April 2016 / Revised: 11 July 2016 / Accepted: 13 July 2016 / Published: 16 July 2016
(This article belongs to the Collection Nanomedicine)
View Full-Text   |   Download PDF [1709 KB, uploaded 16 July 2016]   |  

Abstract

The antineoplasic activity of gallic acid has been reported. This compound induces apoptosis and inhibits the growth of several neoplasic cells. However, this molecule is easily oxidized and degraded in the body. The aim of this work was to intercalate gallate ions into layered double hydroxide (LDH) nanoparticles under controlled conditions to reduce oxidation of gallate and to evaluate its toxicity against the A549 adenocarcinoma cell line. An isopropanol medium under nitrogen atmosphere was adequate to intercalate gallate ions with a lesser oxidation degree as detected by electron spin resonance spectroscopy. Concentrations of the hybrid LDH-gallate nanoparticles between 0.39 and 25 µg/mL reduced the cell viability to 67%, while the value reached with the pure gallic acid and LDH was 90% and 78%, respectively, thus proving that the combination of gallate ions with the inorganic nanoparticles increases the toxicity potential within this dose range. View Full-Text
Keywords: nanomedicine; nanocarrier; gallic; nanoparticle nanomedicine; nanocarrier; gallic; nanoparticle
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MDPI and ACS Style

Arratia-Quijada, J.; Rivas-Fuentes, S.; Saavedra, K.J.P.; Lamas, A.M.M.; Carbajal Arízaga, G.G. Layered Double Hydroxide as a Vehicle to Increase Toxicity of Gallate Ions against Adenocarcinoma Cells. Molecules 2016, 21, 928.

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