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Molecules 2016, 21(7), 912; doi:10.3390/molecules21070912

Differential Effects of Viscum album Preparations on the Maturation and Activation of Human Dendritic Cells and CD4+ T Cell Responses

1
Institut National de la Santé et de la Recherche Médicale Unité 1138, Centre de Recherche des Cordeliers, 15 rue de l’Ecole de Médicine, Paris F-75006, France
2
Université de Technologie de Compiègne, UMR CNRS 6022, Compiègne F-60205, France
3
Centre de Recherche des Cordeliers, Immunopathologie et Immuno-Intervention Thérapeutique, Paris F-75006, France
4
Sorbonne Universités, UPMC Univ Paris 06, UMR S 1138, Paris F-75006, France
5
Université Paris Descartes, Sorbonne Paris Cité, UMR S 1138, Paris F-75006, France
*
Authors to whom correspondence should be addressed.
Academic Editor: Norbert Latruffe
Received: 25 May 2016 / Revised: 28 June 2016 / Accepted: 7 July 2016 / Published: 14 July 2016
(This article belongs to the Special Issue Natural Products and Inflammation)
View Full-Text   |   Download PDF [2408 KB, uploaded 14 July 2016]   |  

Abstract

Extracts of Viscum album (VA); a semi-parasitic plant, are frequently used in the complementary therapy of cancer and other immunological disorders. Various reports show that VA modulates immune system and exerts immune-adjuvant activities that might influence tumor regression. Currently, several therapeutic preparations of VA are available and hence an insight into the mechanisms of action of different VA preparations is necessary. In the present study, we performed a comparative study of five different preparations of VA on maturation and activation of human dendritic cells (DCs) and ensuing CD4+ T cell responses. Monocyte-derived human DCs were treated with VA Qu Spez, VA Qu Frf, VA M Spez, VA P and VA A. Among the five VA preparations tested VA Qu Spez, a fermented extract with a high level of lectins, significantly induced DC maturation markers CD83, CD40, HLA-DR and CD86, and secretion of pro-inflammatory cytokines such as IL-6, IL-8, IL-12 and TNF-α. Furthermore, analysis of T cell cytokines in DC-T cell co-culture revealed that VA Qu Spez significantly stimulated IFN-γ secretion without modulating regulatory T cells and other CD4+ T cytokines IL-4, IL-13 and IL-17A. Our study thus delineates differential effects of VA preparations on DC maturation; function and T cell responses. View Full-Text
Keywords: Viscum album; innate cells; dendritic cells; maturation; cytokines; T cell response; IFN-γ; Th17; Th1; Th2; regulatory T cell Viscum album; innate cells; dendritic cells; maturation; cytokines; T cell response; IFN-γ; Th17; Th1; Th2; regulatory T cell
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Saha, C.; Das, M.; Stephen-Victor, E.; Friboulet, A.; Bayry, J.; Kaveri, S.V. Differential Effects of Viscum album Preparations on the Maturation and Activation of Human Dendritic Cells and CD4+ T Cell Responses. Molecules 2016, 21, 912.

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