Next Article in Journal
Differential Effects of Viscum album Preparations on the Maturation and Activation of Human Dendritic Cells and CD4+ T Cell Responses
Next Article in Special Issue
Antiproliferative Activity and Cellular Uptake of Evodiamine and Rutaecarpine Based on 3D Tumor Models
Previous Article in Journal
Simultaneous Determination of Eight Alkaloids in Rat Plasma by UHPLC-MS/MS after Oral Administration of Coptis deltoidea C. Y. Cheng et Hsiao and Coptis chinensis Franch
Previous Article in Special Issue
Novel (E)-β-Farnesene Analogues Containing 2-Nitroiminohexahydro-1,3,5-triazine: Synthesis and Biological Activity Evaluation
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle
Molecules 2016, 21(7), 909; doi:10.3390/molecules21070909

New Potential Antimalarial Agents: Design, Synthesis and Biological Evaluation of Some Novel Quinoline Derivatives as Antimalarial Agents

1
Chemistry Department, Faculty of Science, Jazan University, Jazan 2097, Saudi Arabia
2
Biology Department, Faculty of Science, Jazan University, Jazan 2097, Saudi Arabia
3
Department of Zoology, Faculty of Science, Al-Azhar University, Cairo 11675, Egypt
4
Chemical Industries Division, National Research Centre, Dokki 12622, Giza, Egypt
*
Author to whom correspondence should be addressed.
Academic Editors: Wei-Zhu Zhong and Shufeng Zhou
Received: 26 May 2016 / Revised: 3 July 2016 / Accepted: 8 July 2016 / Published: 14 July 2016
(This article belongs to the Special Issue Drug Design and Discovery: Principles and Applications)
View Full-Text   |   Download PDF [4166 KB, uploaded 14 July 2016]   |  

Abstract

A novel series of dihydropyrimidines (DHPMs) 4aj; 2-oxopyran-3-carboxylate 7a,b; 1-amino-1,2-dihydropyridine-3-carboxylate 8; and 1,3,4-oxadiazole derivatives 12 with quinolinyl residues have been synthesized in fairly good yields. The structure of the newly synthesized compounds was elucidated on the basis of analytical and spectral analyses. In vitro antimalarial evaluation of the synthesized quinoline derivatives against Plasmodium falciparum revealed them to possess moderate to high antimalarial activities, with IC50 values ranging from 0.014–5.87 μg/mL. Compounds 4b,g,i and 12 showed excellent antimalarial activity against to Plasmodium falciparum compared with the antimalarial agent chloroquine (CQ). View Full-Text
Keywords: quinoline-4-carbaldehyde; Biginelli reaction; dihydropyrimidines; antimalarial activities; Plasmodium falciparum quinoline-4-carbaldehyde; Biginelli reaction; dihydropyrimidines; antimalarial activities; Plasmodium falciparum
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Radini, I.A.M.; Elsheikh, T.M.Y.; El-Telbani, E.M.; Khidre, R.E. New Potential Antimalarial Agents: Design, Synthesis and Biological Evaluation of Some Novel Quinoline Derivatives as Antimalarial Agents. Molecules 2016, 21, 909.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top