Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity
AbstractWe report for the first time the design and synthesis of a novel cyclotide able to activate the unique receptor of angiotensin (1-7) (AT1-7), the MAS1 receptor. This was accomplished by grafting an AT1-7 peptide analog onto loop 6 of cyclotide MCoTI-I using isopeptide bonds to preserve the α-amino and C-terminal carboxylate groups of AT1-7, which are required for activity. The resulting cyclotide construct was able to adopt a cyclotide-like conformation and showed similar activity to that of AT1-7. This cyclotide also showed high stability in human serum thereby providing a promising lead compound for the design of a novel type of peptide-based in the treatment of cancer and myocardial infarction. View Full-Text
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Aboye, T.; Meeks, C.J.; Majumder, S.; Shekhtman, A.; Rodgers, K.; Camarero, J.A. Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity. Molecules 2016, 21, 152.
Aboye T, Meeks CJ, Majumder S, Shekhtman A, Rodgers K, Camarero JA. Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity. Molecules. 2016; 21(2):152.Chicago/Turabian Style
Aboye, Teshome; Meeks, Christopher J.; Majumder, Subhabrata; Shekhtman, Alexander; Rodgers, Kathleen; Camarero, Julio A. 2016. "Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity." Molecules 21, no. 2: 152.
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