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Molecules 2016, 21(2), 199; doi:10.3390/molecules21020199

Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives

1
Marine College, Shandong University,Weihai 264209, China
2
Zhong Yuan Academy of Biological Medicine, Liaocheng People’s Hospital/Affiliated Liaocheng Hospital, Taishan Medical University, Liaocheng 252000, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Jean Jacques Vanden Eynde and Annie Mayence
Received: 7 December 2015 / Accepted: 2 February 2016 / Published: 6 February 2016
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Abstract

A total of forty novel glycyrrhetinic acid (GA) derivatives were designed and synthesized. The cytotoxic activity of the novel compounds was tested against two human breast cancer cell lines (MCF-7, MDA-MB-231) in vitro by the MTT method. The evaluation results revealed that, in comparison with GA, compound 42 shows the most promising anticancer activity (IC50 1.88 ± 0.20 and 1.37 ± 0.18 µM for MCF-7 and MDA-MB-231, respectively) and merits further exploration as a new anticancer agent. View Full-Text
Keywords: glycyrrhetinic acid (GA); derivatives; anticancer; MCF-7; MDA-MB-231 glycyrrhetinic acid (GA); derivatives; anticancer; MCF-7; MDA-MB-231
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, Y.; Feng, L.; Song, Z.-F.; Li, H.-B.; Huai, Q.-Y. Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives. Molecules 2016, 21, 199.

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