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Molecules 2016, 21(2), 138; doi:10.3390/molecules21020138

Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins

1
Laboratory of Organic Chemistry, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
2
Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
3
GlaxoSmithKline, 1250 South Collegeville Road, P. O. Box 5089, Collegeville, PA 19426-0989, USA
4
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: David D. Kitts
Received: 27 October 2015 / Revised: 29 December 2015 / Accepted: 15 January 2016 / Published: 23 January 2016
(This article belongs to the Special Issue Antioxidants—A Risk-Benefit Analysis for Health)
View Full-Text   |   Download PDF [1228 KB, uploaded 23 January 2016]   |  

Abstract

A series of 3-acylhydrazono-4-hydroxycoumarins were synthesized via condensation of 3-acetyl-4-hydroxycoumarin with appropriate hydrazides. The structures of the newly-synthesized compounds were characterized by spectral and elememental analysis or HRMS measurements. Their antioxidant properties were evaluated by using scavenging effects on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical as well as inhibition of lipid peroxidation. Moreover, their ability to inhibit in vitro soybean lipoxygenase has been investigated. They were found to be capable of rapid inactivation of alkylperoxy radicals. View Full-Text
Keywords: antioxidants; 3-acetyl-4-hydroxycoumarin; acyl hydrazones; DPPH; trolox; lipid peroxidation; soybean lipoxygenase antioxidants; 3-acetyl-4-hydroxycoumarin; acyl hydrazones; DPPH; trolox; lipid peroxidation; soybean lipoxygenase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kotali, A.; Nasiopoulou, D.A.; Tsoleridis, C.A.; Harris, P.A.; Kontogiorgis, C.A.; Hadjipavlou-Litina, D.J. Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins. Molecules 2016, 21, 138.

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