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Molecules 2016, 21(1), 119; doi:10.3390/molecules21010119

Antiproliferative and Antioxidant Activities and Mycosporine-Like Amino Acid Profiles of Wild-Harvested and Cultivated Edible Canadian Marine Red Macroalgae

School of Nutrition, Ryerson University, 350 Victoria St., Toronto, ON M5B 2K3, Canada
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Academic Editor: David D. Kitts
Received: 22 December 2015 / Revised: 13 January 2016 / Accepted: 14 January 2016 / Published: 21 January 2016
(This article belongs to the Special Issue Antioxidants—A Risk-Benefit Analysis for Health)
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Abstract

Antiproliferative and antioxidant activities and mycosporine-like amino acid (MAA) profiles of methanol extracts from edible wild-harvested (Chondrus crispus, Mastocarpus stellatus, Palmaria palmata) and cultivated (C. crispus) marine red macroalgae were studied herein. Palythine, asterina-330, shinorine, palythinol, porphyra-334 and usujirene MAAs were identified in the macroalgal extracts by LC/MS/MS. Extract reducing activity rankings were (p < 0.001): wild P. palmata > cultivated C. crispus = wild M. stellatus > wild low-UV C. crispus > wild high-UV C. crispus; whereas oxygen radical absorbance capacities were (p < 0.001): wild M. stellatus > wild P. palmata > cultivated C. crispus > wild low-UV C. crispus > wild high-UV C. crispus. Extracts were antiproliferative against HeLa and U-937 cells (p < 0.001) from 0.125–4 mg/mL, 24 h. Wild P. palmata and cultivated C. crispus extracts increased (p < 0.001) HeLa caspase-3/7 activities and the proportion of cells arrested at Sub G1 (apoptotic) compared to wild-harvested C. crispus and M. stellatus extracts. HeLa cells incubated with wild P. palmata and cultivated C. crispus extracts also exhibited morphological changes characteristic of apoptosis (shrinkage, rounding). Thus, extracts rich in low-polarity usujirene and polar palythine and asterina-330 MAAs were antiproliferative as inducers of apoptosis in HeLa cells. View Full-Text
Keywords: antioxidant activity; antiproliferative activity; apoptosis; Chondrus crispus; Mastocarpus stellatus; Palmaria palmata; mycosporine-like amino acids (MAAs); caspase 3/7; HeLa cells; U-937 cells antioxidant activity; antiproliferative activity; apoptosis; Chondrus crispus; Mastocarpus stellatus; Palmaria palmata; mycosporine-like amino acids (MAAs); caspase 3/7; HeLa cells; U-937 cells
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Athukorala, Y.; Trang, S.; Kwok, C.; Yuan, Y.V. Antiproliferative and Antioxidant Activities and Mycosporine-Like Amino Acid Profiles of Wild-Harvested and Cultivated Edible Canadian Marine Red Macroalgae. Molecules 2016, 21, 119.

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