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Molecules 2016, 21(5), 626; doi:10.3390/molecules21050626

Effects of Brassicaceae Isothiocyanates on Prostate Cancer

1
Lennart Levi Stress and Neuroimmunology Laboratory, School of Medicine and Dentistry, University of Santiago de Compostela, c/San Francisco, s/n, 15782 Santiago de Compostela, A Coruña, Spain
2
Group of Genetics, Breeding and Biochemistry of Brassicas, Misión Biológica de Galicia (CSIC) Aptdo. 28, 36080 Pontevedra, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: David D. Kitts
Received: 16 February 2016 / Revised: 13 April 2016 / Accepted: 3 May 2016 / Published: 12 May 2016
(This article belongs to the Special Issue Antioxidants—A Risk-Benefit Analysis for Health)
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Abstract

Despite the major progress made in the field of cancer biology, cancer is still one of the leading causes of mortality, and prostate cancer (PCa) is one of the most encountered malignancies among men. The effective management of this disease requires developing better anticancer agents with greater efficacy and fewer side effects. Nature is a large source for the development of chemotherapeutic agents, with more than 50% of current anticancer drugs being of natural origin. Isothiocyanates (ITCs) are degradation products from glucosinolates that are present in members of the family Brassicaceae. Although they are known for a variety of therapeutic effects, including antioxidant, immunostimulatory, anti-inflammatory, antiviral and antibacterial properties, nowadays, cell line and animal studies have additionally indicated the chemopreventive action without causing toxic side effects of ITCs. In this way, they can induce cell cycle arrest, activate apoptosis pathways, increase the sensitivity of resistant PCa to available chemodrugs, modulate epigenetic changes and downregulate activated signaling pathways, resulting in the inhibition of cell proliferation, progression and invasion-metastasis. The present review summarizes the chemopreventive role of ITCs with a particular emphasis on specific molecular targets and epigenetic alterations in in vitro and in vivo cancer animal models. View Full-Text
Keywords: angiogenesis; apoptosis; carcinogenesis; cell cycle; chemoprevention; epigenetics; isothiocyanates; metastasis; prostate cancer; therapy resistance angiogenesis; apoptosis; carcinogenesis; cell cycle; chemoprevention; epigenetics; isothiocyanates; metastasis; prostate cancer; therapy resistance
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MDPI and ACS Style

Novío, S.; Cartea, M.E.; Soengas, P.; Freire-Garabal, M.; Núñez-Iglesias, M.J. Effects of Brassicaceae Isothiocyanates on Prostate Cancer. Molecules 2016, 21, 626.

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