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Molecules 2016, 21(10), 1273; doi:10.3390/molecules21101273

Anti-Inflammatory Activity of Citrus bergamia Derivatives: Where Do We Stand?

1
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina I-98168, Italy
2
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina I-98125, Italy
3
Department of Biotechnology and Legal Medicine, University of Palermo, Palermo I-90127, Italy
4
Department of Clinical and Experimental Medicine, University of Messina, Messina I-98125, Italy
5
Institute of Applied Sciences and Intelligent Systems (ISASI), National Research Council (CNR), Pozzuoli I-80078, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 15 July 2016 / Revised: 1 September 2016 / Accepted: 12 September 2016 / Published: 23 September 2016
(This article belongs to the Special Issue Natural Products and Inflammation)
View Full-Text   |   Download PDF [2726 KB, uploaded 28 September 2016]   |  

Abstract

Inflammatory diseases affect a large portion of the worldwide population, and chronic inflammation is a major risk factor for several dangerous pathologies. To limit the side effects of both synthetic and biological anti-inflammatory drugs, the use of herbal medicines, nutraceuticals and food supplements has increased tremendously as alternative and/or complementary medicine to treat several pathologies, including inflammation. During the last decades, the biological properties of Citrus bergamia (bergamot) derivatives have obtained important scientific achievements, and it has been suggested their use in a context of a multitarget pharmacological strategy. Here, we present an overview of the anti-inflammatory properties of bergamot extracts that could represent the scientific basis for develop novel and alternative strategies to improve health status and attenuate inflammatory conditions. View Full-Text
Keywords: bergamot; Citrus bergamia; inflammation; antioxidant activity; flavonoids; natural products; complementary and alternative medicines bergamot; Citrus bergamia; inflammation; antioxidant activity; flavonoids; natural products; complementary and alternative medicines
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ferlazzo, N.; Cirmi, S.; Calapai, G.; Ventura-Spagnolo, E.; Gangemi, S.; Navarra, M. Anti-Inflammatory Activity of Citrus bergamia Derivatives: Where Do We Stand? Molecules 2016, 21, 1273.

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