Table of Contents
Molecules, Volume 21, Issue 10 (October 2016)
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Cover Story (view full-size image) During recent decades, numerous studies were performed to evaluate the neuroprotective effects of [...] Read more. During recent decades, numerous studies were performed to evaluate the neuroprotective effects of Citrus flavonoids and to identify their mechanisms of action. Literature data highlight their antioxidant nature, able to arrest free radical-induced oxidative damage, which is known to play a pivotal role in many degenerative diseases. It is noteworthy that neuroprotective action of Citrus flavonoids is also mediated by the interaction with specific intracellular targets that are implicated in several signaling pathways which are important for maintaining the physiological status. Through these mechanisms, Citrus flavonoids prevent neuronal dysfunctions due to both acute and chronic injuries, as proven in several experimental models. On this basis, we can consider Citrus flavonoids as key compounds for the development of a new generation of pharmacological agents in the prevention and treatment of neurodegenerative diseases. View the pape