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Molecules 2016, 21(9), 1263; doi:10.3390/molecules21091263

Promiscuous Effects of Some Phenolic Natural Products on Inflammation at Least in Part Arise from Their Ability to Modulate the Expression of Global Regulators, Namely microRNAs

1
Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA
2
Department of Cancer Biology and Genetics (CBG), Wexner Medical Center, The Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, OH 43210, USA
3
BioPerox-IL, UB-INSERM IFR #100, Université de Bourgogne-Franche Comté, Faculté Gabriel, 6 Bd. Gabriel, 21000 Dijon, France
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 15 July 2016 / Revised: 12 September 2016 / Accepted: 14 September 2016 / Published: 21 September 2016
(This article belongs to the Special Issue Natural Products and Inflammation)
View Full-Text   |   Download PDF [1278 KB, uploaded 21 September 2016]   |  

Abstract

Recent years have seen the exploration of a puzzling number of compounds found in human diet that could be of interest for prevention or treatment of various pathologies. Although many of these natural products (NPs) have long been used as remedies, their molecular effects still remain elusive. With the advent of biotechnology revolution, NP studies turned from chemistry and biochemistry toward global analysis of gene expression. Hope is to use genetics to identify groups of patient for whom certain NPs or their derivatives may offer new preventive or therapeutic treatments. Recently, microRNAs have gained the statute of global regulators controlling cell homeostasis by regulating gene expression through genetic and epigenetic regulatory loops. Realization that certain plant polyphenols can modify microRNA expression and thus impact gene expression globally, initiated new, mainly in vitro studies, in particular to determine phytochemicals effects on inflammatory response, whose exacerbation has been linked to several disorders including cancer, auto-immune, metabolic, cardiovascular and neuro-inflammatory diseases. However, very few mechanistic insights have been provided, given the complexity of genetic regulatory networks implicated. In this review, we will concentrate on data showing the potential interest of some plant polyphenols in manipulating the expression of pro- and anti-inflammatory microRNAs in pathological conditions. View Full-Text
Keywords: auto-immune disorders; cancer; cardiovascular pathologies; inflammation; microRNAs; miR-155; resveratrol auto-immune disorders; cancer; cardiovascular pathologies; inflammation; microRNAs; miR-155; resveratrol
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Tili, E.; Michaille, J.-J. Promiscuous Effects of Some Phenolic Natural Products on Inflammation at Least in Part Arise from Their Ability to Modulate the Expression of Global Regulators, Namely microRNAs. Molecules 2016, 21, 1263.

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