Next Article in Journal
Design, Synthesis and Insecticidal Activity of Novel Phenylurea Derivatives
Previous Article in Journal
Secondary Metabolite Localization by Autofluorescence in Living Plant Cells
Article Menu

Export Article

Open AccessCommunication
Molecules 2015, 20(3), 5038-5049; doi:10.3390/molecules20035038

(−)-Tarchonanthuslactone Exerts a Blood Glucose-Increasing Effect in Experimental Type 2 Diabetes Mellitus

1
Laboratory of Cell Signaling, University of Campinas, UNICAMP, C.P. 6154, CEP 13084-761 Campinas, São Paulo, Brazil
2
Institute of Chemistry, University of Campinas, UNICAMP, C.P. 6154, CEP 13084-971 Campinas, São Paulo, Brazil
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 8 December 2014 / Revised: 5 March 2015 / Accepted: 6 March 2015 / Published: 19 March 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [995 KB, uploaded 19 March 2015]   |  

Abstract

A number of studies have proposed an anti-diabetic effect for tarchonanthuslactone based on its structural similarity with caffeic acid, a compound known for its blood glucose-reducing properties. However, the actual effect of tarchonanthuslactone on blood glucose level has never been tested. Here, we report that, in opposition to the common sense, tarchonanthuslactone has a glucose-increasing effect in a mouse model of obesity and type 2 diabetes mellitus. The effect is acute and non-cumulative and is present only in diabetic mice. In lean, glucose-tolerant mice, despite a slight increase in blood glucose levels, the effect was not significant. View Full-Text
Keywords: tarchonanthuslactone; caffeic acid; diabetes tarchonanthuslactone; caffeic acid; diabetes
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

de Souza, G.F.P.; Novaes, L.F.T.; Avila, C.M.; Nascimento, L.F.R.; Velloso, L.A.; Pilli, R.A. (−)-Tarchonanthuslactone Exerts a Blood Glucose-Increasing Effect in Experimental Type 2 Diabetes Mellitus. Molecules 2015, 20, 5038-5049.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top