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Molecules 2015, 20(3), 5050-5061; doi:10.3390/molecules20035050

Design, Synthesis and Insecticidal Activity of Novel Phenylurea Derivatives

and
†,*
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 28 February 2015 / Revised: 14 March 2015 / Accepted: 17 March 2015 / Published: 19 March 2015
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [692 KB, uploaded 19 March 2015]   |  

Abstract

A series of novel phenylurea derivatives were designed and synthesized according to the method of active groups linkage and the principle of aromatic groups bioisosterism in this study. The structures of the novel phenylurea derivatives were confirmed based on ESI-MS, IR and 1H-NMR spectral data. All of the compounds were evaluated for the insecticidal activity against the third instars larvae of Spodoptera exigua Hiibner, Plutella xyllostella Linnaeus, Helicoverpa armigera Hubner and Pieris rapae Linne respectively, at the concentration of 10 mg/L. The results showed that all of the derivatives displayed strong insecticidal activity. Most of the compounds presented higher insecticidal activity against S. exigua than the reference compounds tebufenozide, chlorbenzuron and metaflumizone. Among the synthesized compounds, 3b, 3d, 3f, 4b and 4g displayed broad spectrum insecticidal activity. View Full-Text
Keywords: phenylurea; diacylhydrazine; metaflumizone; insecticidal activity; synthesis phenylurea; diacylhydrazine; metaflumizone; insecticidal activity; synthesis
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Sun, J.; Zhou, Y. Design, Synthesis and Insecticidal Activity of Novel Phenylurea Derivatives. Molecules 2015, 20, 5050-5061.

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