Synthesis and Anti-Trypanosoma cruzi Activity of Diaryldiazepines
AbstractChagas disease is a so-called “neglected disease” and endemic to Latin America. Nifurtimox and benznidazole are drugs that have considerable efficacy in the treatment of the acute phase of the disease but cause many significant side effects. Furthermore, in the Chronic Phase its efficiency is reduced and their therapeutic effectiveness is dependent on the type of T. cruzi strain. For this reason, the present work aims to drive basic research towards the discovery of new chemical entities to treat Chagas disease. Differently substituted 5,7-diaryl-2,3-dihydro-1,4-diazepines were synthesized by cyclocondensation of substituted flavones with ethylenediamine and tested as anti-Trypanosoma cruzi candidates. Epimastigotes of the Y strain from T. cruzi were used in this study and the number of parasites was determined in a Neubauer chamber. The most potent diaryldiazepine that reduced epimastigote proliferation exhibited an IC50 value of 0.25 μM, which is significantly more active than benznidazole. View Full-Text
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Menezes, J.C.L.; Vaz, L.B.A.; de Abreu Vieira, P.M.; da Silva Fonseca, K.; Carneiro, C.M.; Taylor, J.G. Synthesis and Anti-Trypanosoma cruzi Activity of Diaryldiazepines. Molecules 2015, 20, 43-51.
Menezes JCL, Vaz LBA, de Abreu Vieira PM, da Silva Fonseca K, Carneiro CM, Taylor JG. Synthesis and Anti-Trypanosoma cruzi Activity of Diaryldiazepines. Molecules. 2015; 20(1):43-51.Chicago/Turabian Style
Menezes, Júlio C.L.; Vaz, Luana B.A.; de Abreu Vieira, Paula M.; da Silva Fonseca, Kátia; Carneiro, Cláudia M.; Taylor, Jason G. 2015. "Synthesis and Anti-Trypanosoma cruzi Activity of Diaryldiazepines." Molecules 20, no. 1: 43-51.