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Molecules 2015, 20(1), 325-334; doi:10.3390/molecules20010325

Asperaculanes A and B, Two Sesquiterpenoids from the Fungus Aspergillus aculeatus

1
Shaanxi Key Laboratory of Natural Products Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China
2
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Nancy D. Turner
Received: 27 October 2014 / Accepted: 2 December 2014 / Published: 25 December 2014
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [848 KB, uploaded 25 December 2014]   |  

Abstract

Six sesquiterpenoids 16, including two new ones, an ent-daucane-type sesquiterpenoid, asperaculane A (1), and a nordaucane one, asperaculane B (2), and four known nordaucane derivatives, aculenes A–D 36, together with the known secalonic acid D (7), were isolated from a fermentation culture of the fungus Aspergillus aculeatus. Their structures and absolute configurations were established by analyses of their spectroscopic data, including 1D and 2D-NMR spectra, HR-ESIMS, electronic circular dichroism (ECD) data, and quantum chemical calculations. These metabolites were evaluated for in vitro cytotoxic activity against two cell lines, human cancer cell lines (HeLa) and one normal hamster cell line (CHO). View Full-Text
Keywords: Aspergillus aculeatus; nordaucane sesquiterpenoids; ent-daucanes; natural products; structure elucidation Aspergillus aculeatus; nordaucane sesquiterpenoids; ent-daucanes; natural products; structure elucidation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gao, Y.-Q.; Guo, C.-J.; Zhang, Q.; Zhou, W.-M.; Wang, C.C.C.; Gao, J.-M. Asperaculanes A and B, Two Sesquiterpenoids from the Fungus Aspergillus aculeatus. Molecules 2015, 20, 325-334.

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