Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Comaparvin Isolated from the Crinoid Comanthus bennetti
AbstractTo date, no study has been conducted to explore the bioactivity of the crinoid Comanthus bennetti. Here we report the anti-inflammatory properties of comaparvin (5,8-dihydroxy-10-methoxy-2-propylbenzo[h]chromen-4-one) based on in vivo experiments. Our preliminary screening for anti-inflammatory activity revealed that the crude extract of Comanthus bennetti significantly inhibited the expression of pro-inflammatory proteins in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophage cells. Comaparvin isolated from crinoids significantly decreased the expression of inducible nitric oxide synthase (iNOS) protein and mRNA in LPS-stimulated macrophage cells. Moreover, our results showed that post-treatment with comaparvin significantly inhibited mechanical allodynia, thermal hyperalgesia and weight-bearing deficits in rats with carrageenan-induced inflammation. Comaparvin also attenuated leukocyte infiltration and iNOS protein expression in carrageenan-induced inflamed paws. These results suggest that comaparvin is a potential anti-inflammatory therapeutic agent against inflammatory pain. View Full-Text
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Chen, L.-C.; Lin, Y.-Y.; Jean, Y.-H.; Lu, Y.; Chen, W.-F.; Yang, S.-N.; Wang, H.-M.D.; Jang, I.-Y.; Chen, I.-M.; Su, J.-H.; Sung, P.-J.; Sheu, J.-H.; Wen, Z.-H. Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Comaparvin Isolated from the Crinoid Comanthus bennetti. Molecules 2014, 19, 14667-14686.
Chen L-C, Lin Y-Y, Jean Y-H, Lu Y, Chen W-F, Yang S-N, Wang H-MD, Jang I-Y, Chen I-M, Su J-H, Sung P-J, Sheu J-H, Wen Z-H. Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Comaparvin Isolated from the Crinoid Comanthus bennetti. Molecules. 2014; 19(9):14667-14686.Chicago/Turabian Style
Chen, Li-Chai; Lin, Yen-You; Jean, Yen-Hsuan; Lu, Yi; Chen, Wu-Fu; Yang, San-Nan; Wang, Hui-Min D.; Jang, Ing-Yang; Chen, I-Ming; Su, Jui-Hsin; Sung, Ping-Jyun; Sheu, Jyh-Horng; Wen, Zhi-Hong. 2014. "Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Comaparvin Isolated from the Crinoid Comanthus bennetti." Molecules 19, no. 9: 14667-14686.