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Molecules 2014, 19(9), 14667-14686; doi:10.3390/molecules190914667

Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Comaparvin Isolated from the Crinoid Comanthus bennetti

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
2
Department of Pharmacy of Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 81342, Taiwan
3
Section of Orthopedic Surgery, Pingtung Christian Hospital, Pingtung 90059, Taiwan
4
Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan
5
School of Medicine, College of Medicine and Department of Pediatrics, E-DA Hospital, I-Shou University, Kaohsiung 84001, Taiwan
6
Department of Fragrance and Cosmetic Science, Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
7
General Education Center, Wenzao Ursuline University of Languages, Kaohsiung 80793, Taiwan
8
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 94450, Taiwan
9
Taiwan Coral Research Center, National Museum of Marine Biology & Aquarium, Pingtung 94450, Taiwan
10
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 80424, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 29 July 2014 / Revised: 9 September 2014 / Accepted: 10 September 2014 / Published: 16 September 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

To date, no study has been conducted to explore the bioactivity of the crinoid Comanthus bennetti. Here we report the anti-inflammatory properties of comaparvin (5,8-dihydroxy-10-methoxy-2-propylbenzo[h]chromen-4-one) based on in vivo experiments. Our preliminary screening for anti-inflammatory activity revealed that the crude extract of Comanthus bennetti significantly inhibited the expression of pro-inflammatory proteins in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophage cells. Comaparvin isolated from crinoids significantly decreased the expression of inducible nitric oxide synthase (iNOS) protein and mRNA in LPS-stimulated macrophage cells. Moreover, our results showed that post-treatment with comaparvin significantly inhibited mechanical allodynia, thermal hyperalgesia and weight-bearing deficits in rats with carrageenan-induced inflammation. Comaparvin also attenuated leukocyte infiltration and iNOS protein expression in carrageenan-induced inflamed paws. These results suggest that comaparvin is a potential anti-inflammatory therapeutic agent against inflammatory pain. View Full-Text
Keywords: comaparvin; crinoids; Comanthus bennetti; inducible nitric oxide synthase; lipopolysaccharide; carrageenan comaparvin; crinoids; Comanthus bennetti; inducible nitric oxide synthase; lipopolysaccharide; carrageenan
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MDPI and ACS Style

Chen, L.-C.; Lin, Y.-Y.; Jean, Y.-H.; Lu, Y.; Chen, W.-F.; Yang, S.-N.; Wang, H.-M.D.; Jang, I.-Y.; Chen, I.-M.; Su, J.-H.; Sung, P.-J.; Sheu, J.-H.; Wen, Z.-H. Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Comaparvin Isolated from the Crinoid Comanthus bennetti. Molecules 2014, 19, 14667-14686.

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