Next Article in Journal
Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Comaparvin Isolated from the Crinoid Comanthus bennetti
Next Article in Special Issue
Biological Evaluation of the Activity of Some Benzimidazole-4,7-dione Derivatives
Previous Article in Journal
A Novel 3,9-(1,2,3-Trioxocine)-Type Steroid of Rauia nodosa (Rutaceae)
Previous Article in Special Issue
Design and Synthesis of New Cholesterol-Conjugated 5-Fluorouracil: A Novel Potential Delivery System for Cancer Treatment
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(9), 14649-14666; doi:10.3390/molecules190914649

Eurycomanone and Eurycomanol from Eurycoma longifolia Jack as Regulators of Signaling Pathways Involved in Proliferation, Cell Death and Inflammation

1
Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC), Hôpital Kirchberg, 9, Rue Edward Steichen, Luxembourg L-2540, Luxembourg
2
Department of Pharmacy, College of Pharmacy, Seoul National University, Building 20 Room 303, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea
3
MedChem Herbal Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor 42300, Malaysia
4
Drug Discovery & Health Core, Universiti Teknologi MARA, Shah Alam, Selangor 40450, Malaysia
*
Author to whom correspondence should be addressed.
Received: 15 July 2014 / Revised: 1 September 2014 / Accepted: 3 September 2014 / Published: 16 September 2014
View Full-Text   |   Download PDF [5054 KB, uploaded 16 September 2014]   |  

Abstract

Eurycomanone and eurycomanol are two quassinoids from the roots of Eurycoma longifolia Jack. The aim of this study was to assess the bioactivity of these compounds in Jurkat and K562 human leukemia cell models compared to peripheral blood mononuclear cells from healthy donors. Both eurycomanone and eurycomanol inhibited Jurkat and K562 cell viability and proliferation without affecting healthy cells. Interestingly, eurycomanone inhibited NF-κB signaling through inhibition of IκBα phosphorylation and upstream mitogen activated protein kinase (MAPK) signaling, but not eurycomanol. In conclusion, both quassinoids present differential toxicity towards leukemia cells, and the presence of the α,β-unsaturated ketone in eurycomanone could be prerequisite for the NF-κB inhibition. View Full-Text
Keywords: eurycomanone; eurycomanol; Eurycoma longifolia Jack; NF-κB; proliferation; cell death eurycomanone; eurycomanol; Eurycoma longifolia Jack; NF-κB; proliferation; cell death
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Hajjouli, S.; Chateauvieux, S.; Teiten, M.-H.; Orlikova, B.; Schumacher, M.; Dicato, M.; Choo, C.-Y.; Diederich, M. Eurycomanone and Eurycomanol from Eurycoma longifolia Jack as Regulators of Signaling Pathways Involved in Proliferation, Cell Death and Inflammation. Molecules 2014, 19, 14649-14666.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top