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Molecules 2014, 19(9), 14687-14698; doi:10.3390/molecules190914687

Pharmacological Effects of the Water Fraction of Key Components in the Traditional Chinese Prescription Mai Tong Fang on 3T3-L1 Adipocytes and ob/ob Diabetic Mice

1
State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, Sichuan, China
2
Guangdong ZhongSheng Pharmaceutical Co. Ltd., Dongguan 440100, Guangdong, China
3
Institute of Translational Medicine, Nanchang University, Nanchang 330031, Jiangxi, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 20 June 2014 / Revised: 1 September 2014 / Accepted: 2 September 2014 / Published: 16 September 2014
(This article belongs to the Section Natural Products)
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Abstract

Mai Tong Fang (MTF), a Chinese herbal combination, has been used for the treatment of diabetic nephropathy in traditional medical clinics in China. However, the anti-adipogenic and anti-hyperglycemic effects of MTF have not been fully elucidated, so this study explored these pharmacological activities in 3T3-L1 adipocytes and ob/ob mice, respectively, of the water fraction of milkvetch root, salviae miltiorrhizae and mulberry as key components of MTF. MTF was found to inhibit adipogenesis and triglyceride accumulation in 3T3-L1 adipocytes. Oral administration of MTF in ob/ob mice for 8 weeks, exhibited positive controls on blood glucose and body weight, and further improved glucose tolerance according to an oral glucose tolerance test. Importantly, MTF extract alleviated fat deposition and ballooning degeneration in liver tissue and blocked the increase of adipocyte size in adipose tissue from treated ob/ob mice. These results indicated that the extract of key components in the traditional Chinese prescription MTF continue a potent anti-adipogenic and glucose-lowering agent. View Full-Text
Keywords: Mai Tong Fang (MTF); 3T3-L1 adipocyte; ob/ob mice; anti-adipogenic effect; anti-hyperglycemic activity Mai Tong Fang (MTF); 3T3-L1 adipocyte; ob/ob mice; anti-adipogenic effect; anti-hyperglycemic activity
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ma, L.; Huang, L.; Pei, H.; Liu, Z.; Xie, C.; Lei, L.; Chen, X.; Ye, H.; Peng, A.; Chen, L. Pharmacological Effects of the Water Fraction of Key Components in the Traditional Chinese Prescription Mai Tong Fang on 3T3-L1 Adipocytes and ob/ob Diabetic Mice. Molecules 2014, 19, 14687-14698.

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