- freely available
Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract
AbstractIt is well documented that dysregulation of microRNAs is a hallmark of human cancers. Thus, this family of small non-coding regulatory molecules represents an excellent source of sensitive biomarkers. Unique microRNAs expression profiles have been associated with different types and subsets of gastrointestinal tumors including gastroenteropancreatic neuroendocrine tumors (GEP-NETs). GEP-NETs are a heterogeneous group of epithelial neoplasms with neuroendocrine differentiation. At present, early detection and surgical resection of GEP-NETs represent the best chance for a cure. Thus, clinically useful biomarkers for GEP-NETs that strongly correlate with early detection are urgently needed. The purpose of this review is to summarize the role of miRNAs in GEP-NET carcinogenesis and their possible use as novel diagnostic, prognostic and predictive biomarkers.
Share & Cite This Article
Vicentini, C.; Fassan, M.; D'Angelo, E.; Corbo, V.; Silvestris, N.; Nuovo, G.J.; Scarpa, A. Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract. Molecules 2014, 19, 2458-2468.View more citation formats
Vicentini C, Fassan M, D'Angelo E, Corbo V, Silvestris N, Nuovo GJ, Scarpa A. Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract. Molecules. 2014; 19(2):2458-2468.Chicago/Turabian Style
Vicentini, Caterina; Fassan, Matteo; D'Angelo, Edoardo; Corbo, Vincenzo; Silvestris, Nicola; Nuovo, Gerard J.; Scarpa, Aldo. 2014. "Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract." Molecules 19, no. 2: 2458-2468.
Notes: Multiple requests from the same IP address are counted as one view.