Next Article in Journal
Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation
Next Article in Special Issue
Assessment of Circulating microRNAs in Plasma of Lung Cancer Patients
Previous Article in Journal
Preparation and In Vitro Evaluation of Glycyrrhetinic Acid-Modified Curcumin-Loaded Nanostructured Lipid Carriers
Previous Article in Special Issue
Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer
Molecules 2014, 19(2), 2458-2468; doi:10.3390/molecules19022458
Review

Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract

1, 1,2,* , 1, 1, 3, 4 and 1,2
1 ARC-Net Research Centre, University and Hospital Trust of Verona, Verona 37134, Italy 2 Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona 37134, Italy 3 Medical Oncology Unit, National Cancer Institute "Giovanni Paolo II", Bari 70124, Italy 4 Comprehensive Cancer Centre, Ohio State University, Columbus, OH 43210, USA
* Author to whom correspondence should be addressed.
Received: 16 January 2014 / Revised: 17 February 2014 / Accepted: 17 February 2014 / Published: 21 February 2014
(This article belongs to the Special Issue miRNAs as Probes to Monitor Cancer and Neurodegenerative Disorders)
View Full-Text   |   Download PDF [588 KB, 18 June 2014; original version 18 June 2014]   |   Browse Figures

Abstract

It is well documented that dysregulation of microRNAs is a hallmark of human cancers. Thus, this family of small non-coding regulatory molecules represents an excellent source of sensitive biomarkers. Unique microRNAs expression profiles have been associated with different types and subsets of gastrointestinal tumors including gastroenteropancreatic neuroendocrine tumors (GEP-NETs). GEP-NETs are a heterogeneous group of epithelial neoplasms with neuroendocrine differentiation. At present, early detection and surgical resection of GEP-NETs represent the best chance for a cure. Thus, clinically useful biomarkers for GEP-NETs that strongly correlate with early detection are urgently needed. The purpose of this review is to summarize the role of miRNAs in GEP-NET carcinogenesis and their possible use as novel diagnostic, prognostic and predictive biomarkers.
Keywords: miRNAs; neuroendocrine tumors; pancreas; gastrointestinal tract; in situ hybridization miRNAs; neuroendocrine tumors; pancreas; gastrointestinal tract; in situ hybridization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Vicentini, C.; Fassan, M.; D'Angelo, E.; Corbo, V.; Silvestris, N.; Nuovo, G.J.; Scarpa, A. Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract. Molecules 2014, 19, 2458-2468.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert