Molecules 2014, 19(2), 2458-2468; doi:10.3390/molecules19022458
Review

Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract

1, 1,2,* email, 1, 1, 3, 4 and 1,2
Received: 16 January 2014; in revised form: 17 February 2014 / Accepted: 17 February 2014 / Published: 21 February 2014
(This article belongs to the Special Issue miRNAs as Probes to Monitor Cancer and Neurodegenerative Disorders)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: It is well documented that dysregulation of microRNAs is a hallmark of human cancers. Thus, this family of small non-coding regulatory molecules represents an excellent source of sensitive biomarkers. Unique microRNAs expression profiles have been associated with different types and subsets of gastrointestinal tumors including gastroenteropancreatic neuroendocrine tumors (GEP-NETs). GEP-NETs are a heterogeneous group of epithelial neoplasms with neuroendocrine differentiation. At present, early detection and surgical resection of GEP-NETs represent the best chance for a cure. Thus, clinically useful biomarkers for GEP-NETs that strongly correlate with early detection are urgently needed. The purpose of this review is to summarize the role of miRNAs in GEP-NET carcinogenesis and their possible use as novel diagnostic, prognostic and predictive biomarkers.
Keywords: miRNAs; neuroendocrine tumors; pancreas; gastrointestinal tract; in situ hybridization
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MDPI and ACS Style

Vicentini, C.; Fassan, M.; D'Angelo, E.; Corbo, V.; Silvestris, N.; Nuovo, G.J.; Scarpa, A. Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract. Molecules 2014, 19, 2458-2468.

AMA Style

Vicentini C, Fassan M, D'Angelo E, Corbo V, Silvestris N, Nuovo GJ, Scarpa A. Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract. Molecules. 2014; 19(2):2458-2468.

Chicago/Turabian Style

Vicentini, Caterina; Fassan, Matteo; D'Angelo, Edoardo; Corbo, Vincenzo; Silvestris, Nicola; Nuovo, Gerard J.; Scarpa, Aldo. 2014. "Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract." Molecules 19, no. 2: 2458-2468.

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