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Molecules 2014, 19(2), 2445-2457; doi:10.3390/molecules19022445
Article

Preparation and In Vitro Evaluation of Glycyrrhetinic Acid-Modified Curcumin-Loaded Nanostructured Lipid Carriers

1,2, 3, 1,2, 4 and 1,*
1 Department of Pharmacy, The First Affiliated Hospital of China Medical University, 155 Nanjing Street, Shenyang 110001, China 2 Department of The First Clinical Pharmacy, China Medical University, 92 Bei'er Road, Shenyang 110001, China 3 Department of Pharmacy, Central Hospital Attached to Shenyang Medical College, No. 5 the 7th south-west Road, TieXi district, Shenyang 110024, China 4 School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Street, Shenyang 110016, China
* Author to whom correspondence should be addressed.
Received: 14 November 2013 / Revised: 11 February 2014 / Accepted: 17 February 2014 / Published: 21 February 2014
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Abstract

Curcumin, a phenolic antioxidant compound derived from the rhizome of the turmeric plant Curcuma longa, has proven to be a modulator of intracellular signaling pathways that control cancer cell growth, inflammation, invasion and apoptosis, revealing its anticancer potential. In this study, a Glycyrrhetinic Acid-Modified Curcumin-Loaded Nanostructured Lipid Carrier (Cur-GA-PEG-NLC) was prepared by the film ultrasound method to improve the tumor-targeting ability. The drug content was detected by an UV spectrophotometry method. The encapsulation efficiency of curcumin in the nanostructured lipid carriers (NLCs) was determined using a mini-column centrifugation method. The encapsulation efficiency for various Cur-GA-PEG-NLC was within the range of 90.06%–95.31% and particle size was between 123.1 nm and 132.7 nm. An in vitro MTT assay showed that Cur-GA10%-PEG-NLC had significantly high cellular uptake and cytotoxicity against HepG2 cells compared with other groups.
Keywords: curcumin; glycyrrhetinic acid; nanostructured lipid carriers; anti-HepG2 curcumin; glycyrrhetinic acid; nanostructured lipid carriers; anti-HepG2
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chu, Y.; Li, D.; Luo, Y.-F.; He, X.-J.; Jiang, M.-Y. Preparation and In Vitro Evaluation of Glycyrrhetinic Acid-Modified Curcumin-Loaded Nanostructured Lipid Carriers. Molecules 2014, 19, 2445-2457.

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