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Molecules 2014, 19(2), 2445-2457; doi:10.3390/molecules19022445

Preparation and In Vitro Evaluation of Glycyrrhetinic Acid-Modified Curcumin-Loaded Nanostructured Lipid Carriers

1,2, 3, 1,2, 4 and 1,*
1 Department of Pharmacy, The First Affiliated Hospital of China Medical University, 155 Nanjing Street, Shenyang 110001, China 2 Department of The First Clinical Pharmacy, China Medical University, 92 Bei'er Road, Shenyang 110001, China 3 Department of Pharmacy, Central Hospital Attached to Shenyang Medical College, No. 5 the 7th south-west Road, TieXi district, Shenyang 110024, China 4 School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Street, Shenyang 110016, China
* Author to whom correspondence should be addressed.
Received: 14 November 2013 / Revised: 11 February 2014 / Accepted: 17 February 2014 / Published: 21 February 2014
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Curcumin, a phenolic antioxidant compound derived from the rhizome of the turmeric plant Curcuma longa, has proven to be a modulator of intracellular signaling pathways that control cancer cell growth, inflammation, invasion and apoptosis, revealing its anticancer potential. In this study, a Glycyrrhetinic Acid-Modified Curcumin-Loaded Nanostructured Lipid Carrier (Cur-GA-PEG-NLC) was prepared by the film ultrasound method to improve the tumor-targeting ability. The drug content was detected by an UV spectrophotometry method. The encapsulation efficiency of curcumin in the nanostructured lipid carriers (NLCs) was determined using a mini-column centrifugation method. The encapsulation efficiency for various Cur-GA-PEG-NLC was within the range of 90.06%–95.31% and particle size was between 123.1 nm and 132.7 nm. An in vitro MTT assay showed that Cur-GA10%-PEG-NLC had significantly high cellular uptake and cytotoxicity against HepG2 cells compared with other groups.
Keywords: curcumin; glycyrrhetinic acid; nanostructured lipid carriers; anti-HepG2 curcumin; glycyrrhetinic acid; nanostructured lipid carriers; anti-HepG2
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chu, Y.; Li, D.; Luo, Y.-F.; He, X.-J.; Jiang, M.-Y. Preparation and In Vitro Evaluation of Glycyrrhetinic Acid-Modified Curcumin-Loaded Nanostructured Lipid Carriers. Molecules 2014, 19, 2445-2457.

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