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Molecules 2014, 19(2), 2469-2480; doi:10.3390/molecules19022469

Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation

1
College of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
2
Department of Chemistry & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
3
College of Life Sciences, Nankai University, Tianjin 300071, China
*
Authors to whom correspondence should be addressed.
Received: 29 January 2014 / Revised: 13 February 2014 / Accepted: 13 February 2014 / Published: 21 February 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.
Keywords: lycorine derivatives; anticancer; synthesis lycorine derivatives; anticancer; synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wang, P.; Yuan, H.-H.; Zhang, X.; Li, Y.-P.; Shang, L.-Q.; Yin, Z. Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation. Molecules 2014, 19, 2469-2480.

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