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Molecules 2014, 19(2), 2469-2480; doi:10.3390/molecules19022469

Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation

1,2, 3, 1, 3, 1,*  and 1,*
Received: 29 January 2014 / Revised: 13 February 2014 / Accepted: 13 February 2014 / Published: 21 February 2014
(This article belongs to the Section Medicinal Chemistry)
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Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.
Keywords: lycorine derivatives; anticancer; synthesis lycorine derivatives; anticancer; synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, P.; Yuan, H.-H.; Zhang, X.; Li, Y.-P.; Shang, L.-Q.; Yin, Z. Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation. Molecules 2014, 19, 2469-2480.

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