Next Article in Journal
A New Solid Phase Extraction for the Determination of Anthocyanins in Grapes
Next Article in Special Issue
Comparison of the Separation Performances of Cinchona Alkaloid-Based Zwitterionic Stationary Phases in the Enantioseparation of β2- and β3-Amino Acids
Previous Article in Journal
New and Cytotoxic Components from Antrodia camphorata
Previous Article in Special Issue
Homoconjugation vs. Exciton Coupling in Chiral α,β-Unsaturated Bicyclo[3.3.1]nonane Dinitrile and Carboxylic Acids
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(12), 21386-21397; doi:10.3390/molecules191221386

Liquid Chromatographic Resolution of Fendiline and Its Analogues on a Chiral Stationary Phase Based on (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid

Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 690-735, Korea
*
Author to whom correspondence should be addressed.
Received: 4 November 2014 / Revised: 5 December 2014 / Accepted: 11 December 2014 / Published: 19 December 2014
(This article belongs to the Special Issue Dynamic Stereochemistry)
View Full-Text   |   Download PDF [782 KB, uploaded 19 December 2014]   |  

Abstract

Fendiline, an effective anti-anginal drug for the treatment of coronary heart diseases, and its sixteen analogues were resolved on a CSP based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid. Fendiline was resolved quite well with the separation factor (α) of 1.25 and resolution (RS) of 1.55 when a mobile phase consisting of methanol–acetonitrile–trifluoroacetic acid–triethylamine at a ratio of 80/20/0.1/0.5 (v/v/v/v) was used. The comparison of the chromatographic behaviors for the resolution of fendiline and its analogues indicated that the 3,3-diphenylpropyl group bonded to the secondary amino group of fendiline is important in the chiral recognition and the difference in the steric bulkiness between the phenyl group and the methyl group at the chiral center of fendiline is also important in the chiral recognition. View Full-Text
Keywords: chiral stationary phase; enantiomer separation; liquid chromatography; fendiline chiral stationary phase; enantiomer separation; liquid chromatography; fendiline
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lee, G.R.; Hyun, M.H. Liquid Chromatographic Resolution of Fendiline and Its Analogues on a Chiral Stationary Phase Based on (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid. Molecules 2014, 19, 21386-21397.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top