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Molecules 2014, 19(12), 21378-21385; doi:10.3390/molecules191221378

New and Cytotoxic Components from Antrodia camphorata

1
Institute of Fisheries Science, National Taiwan University, Taipei 106, Taiwan
2
Department of Nursing, Hungkuang University, Taichung 443, Taiwan
3
Department of Biotechnology, Hungkuang University, Taichung 443, Taiwan
4
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
5
Department of Biochemical Science and Technology, National Chiayi University, Chiayi 600, Taiwan
6
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
7
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
8
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
9
Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
10
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
11
Department of Applied Physics and Chemistry, Taipei Municipal University of Education, Taipei 100, Taiwan
12
Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan
13
Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
14
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
15
Department of Biotechnology, Asia University, Taichung 413, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 18 November 2014 / Revised: 10 December 2014 / Accepted: 11 December 2014 / Published: 19 December 2014
(This article belongs to the Section Natural Products)
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Abstract

The solid-state cultured products of Antrodia camphorata as health foods has been blooming for the past few decades in Taiwan. In continuing our studies on the chemical constituents of the solid-state cultured products of this fungus, 6-methoxy-4-methyl-2,3-(methylenedioxy)phenol (1) and 4,4'-(ethane-1,2-diyl)bis(2,3,6-trimethoxyphenol)(2) together with 2,3,6-trimethoxy-4-methylphenol (3), 1(10→6)abeo-ergosta-5,7,9,22-tetraen-3α-ol (4), citreoanthrasteroid B (5) and dankasterones A (6) and B (7) were purified by a series of column chromatography. Their structures were elucidated by spectral data analysis. For bioactivity assay, compounds 47 showed significant cytotoxicity toward murine colorectal CT26 and human leukemia K562 cancer cell lines with IC50 values ranging from 6.7 to 15.3 µM and from 12.5 to 23.1 µM, respectively. View Full-Text
Keywords: Antrodia camphorata; phenylmethanoid; dihydrostilbene; abeo-ergostane; cytotoxicity Antrodia camphorata; phenylmethanoid; dihydrostilbene; abeo-ergostane; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, T.-H.; Chen, C.-C.; Chen, J.-J.; Liao, H.-F.; Chang, H.-S.; Sung, P.-J.; Tseng, M.-H.; Wang, S.-Y.; Ko, H.-H.; Kuo, Y.-H. New and Cytotoxic Components from Antrodia camphorata. Molecules 2014, 19, 21378-21385.

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