New and Cytotoxic Components from Antrodia camphorata
Institute of Fisheries Science, National Taiwan University, Taipei 106, Taiwan
Department of Nursing, Hungkuang University, Taichung 443, Taiwan
Department of Biotechnology, Hungkuang University, Taichung 443, Taiwan
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
Department of Biochemical Science and Technology, National Chiayi University, Chiayi 600, Taiwan
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Department of Applied Physics and Chemistry, Taipei Municipal University of Education, Taipei 100, Taiwan
Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan
Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
Department of Biotechnology, Asia University, Taichung 413, Taiwan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 18 November 2014 / Revised: 10 December 2014 / Accepted: 11 December 2014 / Published: 19 December 2014
The solid-state cultured products of Antrodia camphorata
as health foods has been blooming for the past few decades in Taiwan. In continuing our studies on the chemical constituents of the solid-state cultured products of this fungus, 6-methoxy-4-methyl-2,3-(methylenedioxy)phenol (1
) and 4,4'-(ethane-1,2-diyl)bis(2,3,6-trimethoxyphenol)(2
) together with 2,3,6-trimethoxy-4-methylphenol (3
), citreoanthrasteroid B (5
) and dankasterones A (6
) and B (7
) were purified by a series of column chromatography. Their structures were elucidated by spectral data analysis. For bioactivity assay, compounds 4
showed significant cytotoxicity toward murine colorectal CT26 and human leukemia K562 cancer cell lines with IC50
values ranging from 6.7 to 15.3 µM and from 12.5 to 23.1 µM, respectively.
This is an open access article distributed under the Creative Commons Attribution License
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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MDPI and ACS Style
Lee, T.-H.; Chen, C.-C.; Chen, J.-J.; Liao, H.-F.; Chang, H.-S.; Sung, P.-J.; Tseng, M.-H.; Wang, S.-Y.; Ko, H.-H.; Kuo, Y.-H. New and Cytotoxic Components from Antrodia camphorata. Molecules 2014, 19, 21378-21385.
Lee T-H, Chen C-C, Chen J-J, Liao H-F, Chang H-S, Sung P-J, Tseng M-H, Wang S-Y, Ko H-H, Kuo Y-H. New and Cytotoxic Components from Antrodia camphorata. Molecules. 2014; 19(12):21378-21385.
Lee, Tzong-Huei; Chen, Chien-Chih; Chen, Jih-Jung; Liao, Hui-Fen; Chang, Hsun-Shuo; Sung, Ping-Jyun; Tseng, Mei-Hwei; Wang, Sheng-Yang; Ko, Horng-Huey; Kuo, Yueh-Hsiung. 2014. "New and Cytotoxic Components from Antrodia camphorata." Molecules 19, no. 12: 21378-21385.
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