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Molecules 2014, 19(11), 18479-18492; doi:10.3390/molecules191118479

External Application of the Volatile Oil from Blumea balsamifera May Be Safe for Liver — A Study on Its Chemical Composition and Hepatotoxicity

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1
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, Hainan, China
2
Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Danzhou 571737, Hainan, China
3
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China
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Hainan Provincial Engineering Research Center for Blumea balsamifera, Danzhou 571737, Hainan, China
*
Author to whom correspondence should be addressed.
Received: 11 September 2014 / Revised: 4 November 2014 / Accepted: 5 November 2014 / Published: 13 November 2014
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Ainaxiang (Blumea balsamifera), also known as Sambong, is an important ancient medicinal herb in Southeast Asia. It is rich in volatile oil, and still widely used nowadays for skin wound healing and treatment of sore throats. We analyzed the volatile oil from Blumea balsamifera (BB oil) by gas chromatography-mass spectrometry (GC-MS). Forty one components, including l-borneol, were identified. Next, the damaging effects of BB oil diluted with olive oil on liver at different concentrations (100%, 50%, 20%), were evaluated, using both normal and wounded skin. Plasma ALT, AST, ALP and TBili were assessed, along with liver histopathology. The results showed that serum levels of liver toxicity markers in the high concentration groups (100% w/v) increased compared with control groups, whereas no significant changes was observed in histopathology of liver samples. In the wound groups, treatment with BB oil resulted in a decrease in serum toxicity index, compared with normal animal groups. This study confirms the safety of short term BB oil consumption, though high BB oil doses may lead to mild liver injury and this response might be weakened in the case of cutaneous wounds. These results are expected to be helpful for guiding appropriate therapeutic use of BB oil. View Full-Text
Keywords: Blumea balsamifera; Ainaxiang; Nalong; Sambong; essential oil; chemical composition; hepatotoxicity Blumea balsamifera; Ainaxiang; Nalong; Sambong; essential oil; chemical composition; hepatotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Pang, Y.-X.; Fan, Z.-W.; Wang, D.; Yang, Q.; Wang, K.; Chen, X.-L.; Hu, X.; Yu, F.-L.; Chen, Z.-X. External Application of the Volatile Oil from Blumea balsamifera May Be Safe for Liver — A Study on Its Chemical Composition and Hepatotoxicity. Molecules 2014, 19, 18479-18492.

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