Poly(Ethylene Glycol)-Based Backbones with High Peptide Loading Capacities
AbstractPolymer-peptide conjugates are a promising class of compounds, where polymers can be used to overcome some of the limitations associated with peptides intended for therapeutic and/or diagnostic applications. Linear polymers such as poly(ethylene glycol) can be conjugated through terminal moieties and have therefore limited loading capacities. In this research, functionalised linear poly(ethylene glycol)s are utilised for peptide conjugation, to increase their potential loading capacities. These poly(ethylene glycol) derivatives are conjugated to peptide sequences containing representative side-chain functionalised amino acids, using different conjugation chemistries, including copper-catalysed azide-alkyne cycloaddition, amide coupling and thiol-ene reactions. Conjugation of a sequence containing the RGD motif to poly(allyl glycidyl ether) by the thiol-ene reaction, provided a conjugate which could be used in platelet adhesion studies. View Full-Text
- Supplementary File 1:
Supplementary Materials (PDF, 3637 KB)
Share & Cite This Article
O'Connor, A.; Marsat, J.-N.; Mitrugno, A.; Flahive, T.; Moran, N.; Brayden, D.; Devocelle, M. Poly(Ethylene Glycol)-Based Backbones with High Peptide Loading Capacities. Molecules 2014, 19, 17559-17577.
O'Connor A, Marsat J-N, Mitrugno A, Flahive T, Moran N, Brayden D, Devocelle M. Poly(Ethylene Glycol)-Based Backbones with High Peptide Loading Capacities. Molecules. 2014; 19(11):17559-17577.Chicago/Turabian Style
O'Connor, Aoife; Marsat, Jean-Noel; Mitrugno, Annachiara; Flahive, Tom; Moran, Niamh; Brayden, David; Devocelle, Marc. 2014. "Poly(Ethylene Glycol)-Based Backbones with High Peptide Loading Capacities." Molecules 19, no. 11: 17559-17577.