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Molecules 2014, 19(11), 17130-17140; doi:10.3390/molecules191117130

Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production

1
Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
2
Faculty of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashiosaka, Osaka 577-8502, Japan
*
Author to whom correspondence should be addressed.
Received: 5 September 2014 / Revised: 17 October 2014 / Accepted: 20 October 2014 / Published: 24 October 2014
(This article belongs to the Collection Bioactive Compounds)
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Abstract

A novel gedunin and two novel phragmalin-type limonoids, named carapanolides J–L (compounds 13) as well as a known gedunin-type limonoid 4 were isolated from the seeds of Carapa guianensis (andiroba). Their structures were determined on the basis of 1D and 2D NMR spectroscopy and HRFABMS. Compounds 14 were evaluated for their effects on the production of NO in LPS-activated mouse peritoneal macrophages. View Full-Text
Keywords: Carapa guianensis; andiroba; seeds; gedunin; phragmalin; limonoids; NO production Carapa guianensis; andiroba; seeds; gedunin; phragmalin; limonoids; NO production
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Matsui, Y.; Kikuchi, T.; Inoue, T.; Muraoka, O.; Yamada, T.; Tanaka, R. Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production. Molecules 2014, 19, 17130-17140.

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