Next Article in Journal
Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production
Previous Article in Journal
Endocannabinoids, Related Compounds and Their Metabolic Routes
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(11), 17107-17129; doi:10.3390/molecules191117107

Microemulsion System for Topical Delivery of Thai Mango Seed Kernel Extract: Development, Physicochemical Characterisation and Ex Vivo Skin Permeation Studies

1
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayuthaya Road, Rajathevi, Bangkok 10400, Thailand
2
EA 4169 "Fonctions Normales et Pathologiques de la Barrière Cutanée", Laboratoire de Recherche et Développement de Pharmacie Galénique Industrielle, ISPB-Faculté de Pharmacie, Université Claude Bernard Lyon-I, 8 Avenue Rockefeller, F-69373 Lyon Cedex 08, France
3
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, 254 Payathai Road, Pathumwan, Bangkok 10330, Thailand
*
Author to whom correspondence should be addressed.
Received: 20 July 2014 / Revised: 16 October 2014 / Accepted: 17 October 2014 / Published: 24 October 2014
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1060 KB, uploaded 24 October 2014]   |  

Abstract

A microemulsion system containing Thai mango seed kernel extract (MSKE, cultivar “Fahlun”) was developed and characterised for the purpose of topical skin delivery. The MSKE-loaded microemulsions were prepared by using the spontaneous emulsification method. Isopropyl myristate (IPM) was selected as the oil phase. A polyoxyethylene sorbitan monooleate and sorbitan monododecanoate (1:1, w/w) system was used as the surfactant phase; an aqueous mixture of different cosurfactants (absolute ethanol, 96.3% v/v ethanol, 1-propanol, 2-propanol or 1,2-propanediol) at a weight ratio of 1:1 was used as the aqueous phase. Among the cosurfactants studied, the 1-propanol aqueous mixture had the largest microemulsion region (48.93%) in the pseudo-ternary phase diagram. Microemulsions containing 1% MSKE demonstrated good physicochemical stability during a six-month study period at 25 ± 2 °C/60% ± 5% RH. The ex vivo skin permeation study demonstrated that the microemulsions exhibited a potent skin enhancement effect allowing MSKE to penetrate skin layers up to 60-fold higher compared with the control. Neither skin irritation nor skin corrosion was observed in ex vivo studies. The present study revealed that IPM-based microemulsion systems may be promising carriers to enhance skin penetration and delivering MSKE for topical treatment. View Full-Text
Keywords: mango seed kernel extract; microemulsion; skin corrosion study; skin irritation study; skin permeation study; stability; topical delivery mango seed kernel extract; microemulsion; skin corrosion study; skin irritation study; skin permeation study; stability; topical delivery
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Leanpolchareanchai, J.; Padois, K.; Falson, F.; Bavovada, R.; Pithayanukul, P. Microemulsion System for Topical Delivery of Thai Mango Seed Kernel Extract: Development, Physicochemical Characterisation and Ex Vivo Skin Permeation Studies. Molecules 2014, 19, 17107-17129.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top