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The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions
AbstractInflammation is increasingly being understood to be a key component to the pathophysiology of cerebrovascular lesions. Ferumoxytol, an iron oxide nanoparticle coated by a carbohydrate shell, has been used in MRI studies as an inflammatory marker because it is cleared by macrophages. Ferumoxytol-enhanced MRI has emerged as an important tool for noninvasive assessment of the inflammatory status of cerebrovascular lesions, namely aneurysms and arteriovenous malformations. Moreover, preliminary evidence suggests that ferumoxytol-enhanced MRI could be applied as a non-invasive tool to differentiate “unstable” lesions that require early intervention from “stable” lesions in which observation may be safe. Assessment of the effects of anti-inflammatory pharmacological interventions on cerebrovascular lesions is also a potentially crucial application of the technique. Future improvements in technique and MRI signal quantification will certainly pave the way for widespread and efficient use of ferumoxytol-enhanced MRI in clinical practice. In this paper, we review current data regarding ferumoxytol-enhanced MRI and discuss its current/potential applications and future perspectives.
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Chalouhi, N.; Jabbour, P.; Magnotta, V.; Hasan, D. The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions. Molecules 2013, 18, 9670-9683.View more citation formats
Chalouhi N, Jabbour P, Magnotta V, Hasan D. The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions. Molecules. 2013; 18(8):9670-9683.Chicago/Turabian Style
Chalouhi, Nohra; Jabbour, Pascal; Magnotta, Vincent; Hasan, David. 2013. "The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions." Molecules 18, no. 8: 9670-9683.