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Molecules 2013, 18(7), 7686-7698; doi:10.3390/molecules18077686

Biosynthesis of Panaxynol and Panaxydol in Panax ginseng

Lehrstuhl für Biochemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany
Laboratorio de Fisiología Vegetal, Facultad de Farmacia, Universidad de Barcelona, 08028 Barcelona, Spain
FloraFarm, Bockhorn, 29664 Walsrode-Bockhorn, Germany
These authors contributed equally to this work.
On sabbatical leave from Centro de Investigación Científica de Yucatán, Mérida, México
Authors to whom correspondence should be addressed.
Received: 6 May 2013 / Revised: 13 June 2013 / Accepted: 28 June 2013 / Published: 2 July 2013
(This article belongs to the Special Issue Phytochemicals: Analytical and Medicinal Chemistry)
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The natural formation of the bioactive C17-polyacetylenes (−)-(R)-panaxynol and panaxydol was analyzed by 13C-labeling experiments. For this purpose, plants of Panax ginseng were supplied with 13CO2 under field conditions or, alternatively, sterile root cultures of P. ginseng were supplemented with [U-13C6]glucose. The polyynes were isolated from the labeled roots or hairy root cultures, respectively, and analyzed by quantitative NMR spectroscopy. The same mixtures of eight doubly 13C-labeled isotopologues and one single labeled isotopologue were observed in the C17-polyacetylenes obtained from the two experiments. The polyketide-type labeling pattern is in line with the biosynthetic origin of the compounds via decarboxylation of fatty acids, probably of crepenynic acid. The 13C-study now provides experimental evidence for the biosynthesis of panaxynol and related polyacetylenes in P. ginseng under in planta conditions as well as in root cultures. The data also show that 13CO2 experiments under field conditions are useful to elucidate the biosynthetic pathways of metabolites, including those from roots.
Keywords: Panax ginseng; Araliaceae; panaxynol; panaxydol; falcarinol; polyyne; crepenynic acid; isotopologue profiling; 13CO2 Panax ginseng; Araliaceae; panaxynol; panaxydol; falcarinol; polyyne; crepenynic acid; isotopologue profiling; 13CO2
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Knispel, N.; Ostrozhenkova, E.; Schramek, N.; Huber, C.; Peña-Rodríguez, L.M.; Bonfill, M.; Palazón, J.; Wischmann, G.; Cusidó, R.M.; Eisenreich, W. Biosynthesis of Panaxynol and Panaxydol in Panax ginseng. Molecules 2013, 18, 7686-7698.

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