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Herb-Herb Combination for Therapeutic Enhancement and Advancement: Theory, Practice and Future Perspectives
Department of Medicinal Chemistry and Pharmacognosy and WHO Collaborating Center for Traditional Medicine, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
Center for Advancement of Drug Research and Evaluation, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China
* Author to whom correspondence should be addressed.
Received: 3 April 2013; in revised form: 25 April 2013 / Accepted: 25 April 2013 / Published: 3 May 2013
Abstract: Herb-herb combinations have been used in Chinese medicine practice for thousands of years, yet scientific evidence of their therapeutic benefits is lacking. With increasing interest in shifting from the one-drug-one-target paradigm to combination therapy or polypharmacy to achieve therapeutic benefits for a number of diseases, there is momentum to explore new knowledge by tapping the past empirical experiences of herb-herb combinations. This review presents an overview of the traditional concept and practice of herb-herb combination in Chinese medicine, and highlights the available scientific and clinical evidence to support the combined use of herbs. It is hoped that such information would provide a lead for developing new approaches for future therapeutic advancement and pharmaceutical product development. Very likely modern technologies combined with innovative research for the quality control of herbal products, identification of active components and understanding of the molecular mechanism, followed by well-designed animal and clinical studies would pave the way in advancing the wealth of empirical knowledge from herb-herb combination to new therapeutic modalities.
Keywords: herb-herb combination; herb-herb interaction; Chinese medicine; multi-item prescription; synergy
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MDPI and ACS Style
Che, C.-T.; Wang, Z.J.; Chow, M.S.S.; Lam, C.W.K. Herb-Herb Combination for Therapeutic Enhancement and Advancement: Theory, Practice and Future Perspectives. Molecules 2013, 18, 5125-5141.
Che C-T, Wang ZJ, Chow MSS, Lam CWK. Herb-Herb Combination for Therapeutic Enhancement and Advancement: Theory, Practice and Future Perspectives. Molecules. 2013; 18(5):5125-5141.
Che, Chun-Tao; Wang, Zhi J.; Chow, Moses S.S.; Lam, Christopher W.K. 2013. "Herb-Herb Combination for Therapeutic Enhancement and Advancement: Theory, Practice and Future Perspectives." Molecules 18, no. 5: 5125-5141.