Molecules 2013, 18(7), 7600-7608; doi:10.3390/molecules18077600
Article

Isolation and Synthesis of a Bioactive Benzenoid Derivative from the Fruiting Bodies of Antrodia camphorata

1 School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan 2 Yong Chung Prosperous Biotech Co. Ltd., New Taipei 231, Taiwan 3 Twherb Biomedical Co. Ltd., Jhubei 302, Taiwan 4 Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, 404 Taichung, Taiwan 5 School of Medicine, Taipei Medical University, Taipei 110, Taiwan These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 15 May 2013; in revised form: 20 June 2013 / Accepted: 21 June 2013 / Published: 28 June 2013
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Abstract: A new enynyl-benzenoid, antrocamphin O (1,4,7-dimethoxy-5-methyl-6-(3′-methylbut-3-en-1-ynyl)benzo[d][1,3]dioxide), and the known benzenoids antrocamphin A and 7-dimethoxy-5-methyl-1,3-benzodioxole, were isolated from the fruiting bodies of Antrodia camphorata (Taiwanofungus camphoratus). The structure of antrocamphin O was unambiguously assigned by the analysis of spectral data (including 1D and 2D NMR, high-resolution MS, IR, and UV) and total synthesis. Compound 1 was prepared through the Sonogashira reaction of 5-iodo-4,7-dimethoxy-6-methylbenzene and 2-methylbut-1-en-3-yne as the key step. The benzenoids were tested for cytotoxicity against the HT29, HTC15, DLD-1, and COLO 205 colon cancer cell lines, and activities are reported herein.
Keywords: Antrodia camphorata; enynyl-benzenoid; antrocamphin O; synthesis; cytotoxic activity

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MDPI and ACS Style

Chen, P.-Y.; Wu, J.-D.; Tang, K.-Y.; Yu, C.-C.; Kuo, Y.-H.; Zhong, W.-B.; Lee, C.-K. Isolation and Synthesis of a Bioactive Benzenoid Derivative from the Fruiting Bodies of Antrodia camphorata . Molecules 2013, 18, 7600-7608.

AMA Style

Chen P-Y, Wu J-D, Tang K-Y, Yu C-C, Kuo Y-H, Zhong W-B, Lee C-K. Isolation and Synthesis of a Bioactive Benzenoid Derivative from the Fruiting Bodies of Antrodia camphorata . Molecules. 2013; 18(7):7600-7608.

Chicago/Turabian Style

Chen, Pi-Yu; Wu, Jen-Der; Tang, Kai-Yih; Yu, Chieh-Chou; Kuo, Yueh-Hsiung; Zhong, Wen-Bin; Lee, Ching-Kuo. 2013. "Isolation and Synthesis of a Bioactive Benzenoid Derivative from the Fruiting Bodies of Antrodia camphorata ." Molecules 18, no. 7: 7600-7608.

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