Next Article in Journal
Previous Article in Journal
Molecules 2013, 18(7), 7600-7608; doi:10.3390/molecules18077600
Article

Isolation and Synthesis of a Bioactive Benzenoid Derivative from the Fruiting Bodies of Antrodia camphorata

1,†
, 1
, 2,†
, 3
, 4
, 5,*  and 1,*
Received: 15 May 2013; in revised form: 20 June 2013 / Accepted: 21 June 2013 / Published: 28 June 2013
Download PDF [389 KB, uploaded 18 June 2014]
Abstract: A new enynyl-benzenoid, antrocamphin O (1,4,7-dimethoxy-5-methyl-6-(3′-methylbut-3-en-1-ynyl)benzo[d][1,3]dioxide), and the known benzenoids antrocamphin A and 7-dimethoxy-5-methyl-1,3-benzodioxole, were isolated from the fruiting bodies of Antrodia camphorata (Taiwanofungus camphoratus). The structure of antrocamphin O was unambiguously assigned by the analysis of spectral data (including 1D and 2D NMR, high-resolution MS, IR, and UV) and total synthesis. Compound 1 was prepared through the Sonogashira reaction of 5-iodo-4,7-dimethoxy-6-methylbenzene and 2-methylbut-1-en-3-yne as the key step. The benzenoids were tested for cytotoxicity against the HT29, HTC15, DLD-1, and COLO 205 colon cancer cell lines, and activities are reported herein.
Keywords: Antrodia camphorata; enynyl-benzenoid; antrocamphin O; synthesis; cytotoxic activity Antrodia camphorata; enynyl-benzenoid; antrocamphin O; synthesis; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Chen, P.-Y.; Wu, J.-D.; Tang, K.-Y.; Yu, C.-C.; Kuo, Y.-H.; Zhong, W.-B.; Lee, C.-K. Isolation and Synthesis of a Bioactive Benzenoid Derivative from the Fruiting Bodies of Antrodia camphorata . Molecules 2013, 18, 7600-7608.

AMA Style

Chen P-Y, Wu J-D, Tang K-Y, Yu C-C, Kuo Y-H, Zhong W-B, Lee C-K. Isolation and Synthesis of a Bioactive Benzenoid Derivative from the Fruiting Bodies of Antrodia camphorata . Molecules. 2013; 18(7):7600-7608.

Chicago/Turabian Style

Chen, Pi-Yu; Wu, Jen-Der; Tang, Kai-Yih; Yu, Chieh-Chou; Kuo, Yueh-Hsiung; Zhong, Wen-Bin; Lee, Ching-Kuo. 2013. "Isolation and Synthesis of a Bioactive Benzenoid Derivative from the Fruiting Bodies of Antrodia camphorata ." Molecules 18, no. 7: 7600-7608.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert