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Molecules 2013, 18(7), 7609-7630; doi:10.3390/molecules18077609

Hepatoprotective Effects of Mushrooms

Department of Biochemistry, State University of Maringá, Maringá 87015-900, Brazil
Department of Biology, State University of Maringá, Maringá 87015-900, Brazil
Department of Nutrition, Federal University of the Southern Frontier, Realeza 85770-000, Brazil
Author to whom correspondence should be addressed.
Received: 27 May 2013 / Revised: 26 June 2013 / Accepted: 27 June 2013 / Published: 1 July 2013
(This article belongs to the Section Medicinal Chemistry)
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The particular characteristics of growth and development of mushrooms in nature result in the accumulation of a variety of secondary metabolites such as phenolic compounds, terpenes and steroids and essential cell wall components such as polysaccharides, b-glucans and proteins, several of them with biological activities. The present article outlines and discusses the available information about the protective effects of mushroom extracts against liver damage induced by exogenous compounds. Among mushrooms, Ganoderma lucidum is indubitably the most widely studied species. In this review, however, emphasis was given to studies using other mushrooms, especially those presenting efforts of attributing hepatoprotective activities to specific chemical components usually present in the mushroom extracts.
Keywords: anthraquinol; anti-oxidant activity; ganoderenic acid; b-glucan; metabolism; natural products; oxidative stress anthraquinol; anti-oxidant activity; ganoderenic acid; b-glucan; metabolism; natural products; oxidative stress

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Soares, A.A.; de Sá-Nakanishi, A.B.; Bracht, A.; da Costa, S.M.G.; Koehnlein, E.A.; de Souza, C.G.M.; Peralta, R.M. Hepatoprotective Effects of Mushrooms. Molecules 2013, 18, 7609-7630.

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