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Novel Biological Activities of Allosamidins
Department of Applied Biological Chemistry, the University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Department of Pulmonary Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
* Author to whom correspondence should be addressed.
Received: 26 April 2013; in revised form: 27 May 2013 / Accepted: 7 June 2013 / Published: 13 June 2013
Abstract: Allosamidins, which are secondary metabolites of the Streptomyces species, have chitin-mimic pseudotrisaccharide structures. They bind to catalytic centers of all family 18 chitinases and inhibit their enzymatic activity. Allosamidins have been used as chitinase inhibitors to investigate the physiological roles of chitinases in a variety of organisms. Two prominent biological activities of allosamidins were discovered, where one has anti-asthmatic activity in mammals, while the other has the chitinase-production- promoting activity in allosamidin-producing Streptomyces. In this article, recent studies on the novel biological activities of allosamidins are reviewed.
Keywords: allosamidin; chitinase; inhibitor; asthma; Streptomyces; secondary metabolite
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Sakuda, S.; Inoue, H.; Nagasawa, H. Novel Biological Activities of Allosamidins. Molecules 2013, 18, 6952-6968.
Sakuda S, Inoue H, Nagasawa H. Novel Biological Activities of Allosamidins. Molecules. 2013; 18(6):6952-6968.
Sakuda, Shohei; Inoue, Hiromasa; Nagasawa, Hiromichi. 2013. "Novel Biological Activities of Allosamidins." Molecules 18, no. 6: 6952-6968.