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Novel Biological Activities of Allosamidins
AbstractAllosamidins, which are secondary metabolites of the Streptomyces species, have chitin-mimic pseudotrisaccharide structures. They bind to catalytic centers of all family 18 chitinases and inhibit their enzymatic activity. Allosamidins have been used as chitinase inhibitors to investigate the physiological roles of chitinases in a variety of organisms. Two prominent biological activities of allosamidins were discovered, where one has anti-asthmatic activity in mammals, while the other has the chitinase-production- promoting activity in allosamidin-producing Streptomyces. In this article, recent studies on the novel biological activities of allosamidins are reviewed.
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Sakuda, S.; Inoue, H.; Nagasawa, H. Novel Biological Activities of Allosamidins. Molecules 2013, 18, 6952-6968.View more citation formats
Sakuda S, Inoue H, Nagasawa H. Novel Biological Activities of Allosamidins. Molecules. 2013; 18(6):6952-6968.Chicago/Turabian Style
Sakuda, Shohei; Inoue, Hiromasa; Nagasawa, Hiromichi. 2013. "Novel Biological Activities of Allosamidins." Molecules 18, no. 6: 6952-6968.