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Molecules 2013, 18(5), 5749-5760; doi:10.3390/molecules18055749

Synthesis and Characterization of Oil-Chitosan Composite Spheres

2,* , 3
1 The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung 82445, Taiwan 2 Department of Biomedical Engineering, I-Shou University, Kaohsiung 82445, Taiwan 3 Department of Biological Science and Technology, I-Shou University, Kaohsiung 82445, Taiwan 4 Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxidic Materials and Nanomaterials, University Politehnica of Bucharest, Bucharest 011061, Romania 5 Department of Applied Cosmetology and Master Program of Cosmetic Science, Hungkuang University, Taichung 43302, Taiwan
* Author to whom correspondence should be addressed.
Received: 1 April 2013 / Revised: 29 April 2013 / Accepted: 9 May 2013 / Published: 16 May 2013
(This article belongs to the Special Issue Chitins and Chitosans)
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Oil-chitosan composite spheres were synthesized by encapsulation of sunflower seed oil in chitosan droplets, dropping into NaOH solution and in situ solidification. Hydrophilic materials (i.e., iron oxide nanoparticles) and lipophilic materials (i.e., rhodamine B or epirubicin) could be encapsulated simultaneously in the spheres in a one step process. The diameters of the prepared spheres were 2.48 ± 0.11 mm (pure chitosan spheres), 2.31 ± 0.08 mm (oil-chitosan composites), 1.49 ± 0.15 mm (iron-oxide embedded oil-chitosan composites), and 1.69 ± 0.1 mm (epirubicin and iron oxide encapsulated oil-chitosan composites), respectively. Due to their superparamagnetic properties, the iron-oxide embedded oil-chitosan composites could be guided by a magnet. A lipophilic drug (epirubicin) could be loaded in the spheres with encapsulation rate measured to be 72.25%. The lipophilic fluorescent dye rhodamine B was also loadable in the spheres with red fluorescence being observed under a fluorescence microscope. We have developed a novel approach to an in situ process for fabricating oil-chitosan composite spheres with dual encapsulation properties, which are potential multifunctional drug carriers.
Keywords: oil-chitosan composite spheres; iron oxide; dual encapsulation oil-chitosan composite spheres; iron oxide; dual encapsulation
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Huang, K.-S.; Wang, C.-Y.; Yang, C.-H.; Grumezescu, A.M.; Lin, Y.-S.; Kung, C.-P.; Lin, I.-Y.; Chang, Y.-C.; Weng, W.-J.; Wang, W.-T. Synthesis and Characterization of Oil-Chitosan Composite Spheres. Molecules 2013, 18, 5749-5760.

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