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Molecules 2013, 18(11), 14268-14284; doi:10.3390/molecules181114268

Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries

Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA
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Received: 8 October 2013 / Revised: 8 November 2013 / Accepted: 8 November 2013 / Published: 18 November 2013
(This article belongs to the Special Issue Organophosphorus Chemistry)
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Abstract

The chemical synthesis of DNA and RNA is universally carried out using nucleoside phosphoramidites or H-phosphonates as synthons. This review focuses on the phosphorus chemistry behind these synthons and how it has been developed to generate procedures whereby yields per condensation approach 100% with very few side products. Additionally the synthesis and properties of certain DNA and RNA analogs that are modified at phosphorus will also be discussed. These analogs include boranephosphonates, metallophosphonates, and alkylboranephosphines.
Keywords: DNA; RNA; phosphoramidites; H-phosphonates; boranephosphonates; metallophosphonates; boranealkylphosphines DNA; RNA; phosphoramidites; H-phosphonates; boranephosphonates; metallophosphonates; boranealkylphosphines
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Roy, S.; Caruthers, M. Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries. Molecules 2013, 18, 14268-14284.

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