Molecules 2013, 18(11), 14285-14292; doi:10.3390/molecules181114285
Article

Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release

1 Department of Chemistry, Vinh University, Vinh City, Nghe An 42000, Vietnam 2 Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan 3 Graduate Institute of Natural Products and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan 4 Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 27 September 2013; in revised form: 6 November 2013 / Accepted: 15 November 2013 / Published: 19 November 2013
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Abstract: The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 ± 0.38 and 1.94 ± 0.50 µg/mL, respectively.
Keywords: Ganoderma; triterpenoid; steroid; superoxide anion generation; elastase release

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MDPI and ACS Style

Thang, T.D.; Kuo, P.-C.; Hwang, T.-L.; Yang, M.-L.; Ngoc, N.T.B.; Han, T.T.N.; Lin, C.-W.; Wu, T.-S. Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release. Molecules 2013, 18, 14285-14292.

AMA Style

Thang TD, Kuo P-C, Hwang T-L, Yang M-L, Ngoc NTB, Han TTN, Lin C-W, Wu T-S. Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release. Molecules. 2013; 18(11):14285-14292.

Chicago/Turabian Style

Thang, Tran D.; Kuo, Ping-Chung; Hwang, Tsong-Long; Yang, Mei-Lin; Ngoc, Nguyen T.B.; Han, Tran T.N.; Lin, Chi-Wen; Wu, Tian-Shung. 2013. "Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release." Molecules 18, no. 11: 14285-14292.

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