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Molecules 2013, 18(11), 14285-14292; doi:10.3390/molecules181114285
Article

Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release

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Received: 27 September 2013 / Revised: 6 November 2013 / Accepted: 15 November 2013 / Published: 19 November 2013
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Abstract

The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 ± 0.38 and 1.94 ± 0.50 µg/mL, respectively.
Keywords: Ganoderma; triterpenoid; steroid; superoxide anion generation; elastase release Ganoderma; triterpenoid; steroid; superoxide anion generation; elastase release
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Thang, T.D.; Kuo, P.-C.; Hwang, T.-L.; Yang, M.-L.; Ngoc, N.T.B.; Han, T.T.N.; Lin, C.-W.; Wu, T.-S. Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release. Molecules 2013, 18, 14285-14292.

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