Molecules 2013, 18(11), 13645-13653; doi:10.3390/molecules181113645
Article

Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media

1,* email, 2, 3, 2, 2 and 2,* email
Received: 5 August 2013; in revised form: 22 October 2013 / Accepted: 31 October 2013 / Published: 5 November 2013
(This article belongs to the Section Organic Synthesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environmentally benign procedure.
Keywords: 5-arylisoxazole; without catalyst; aqueous media; synthesis
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MDPI and ACS Style

Dou, G.; Xu, P.; Li, Q.; Xi, Y.; Huang, Z.; Shi, D. Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media. Molecules 2013, 18, 13645-13653.

AMA Style

Dou G, Xu P, Li Q, Xi Y, Huang Z, Shi D. Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media. Molecules. 2013; 18(11):13645-13653.

Chicago/Turabian Style

Dou, Guolan; Xu, Pan; Li, Qiang; Xi, Yukun; Huang, Zhibin; Shi, Daqing. 2013. "Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media." Molecules 18, no. 11: 13645-13653.

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