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Molecules 2013, 18(11), 13645-13653; doi:10.3390/molecules181113645

Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media

1,* , 2, 3, 2, 2 and 2,*
1 School of Safety Engineering, China University of Mining & Technology, Xuzhou 221116, China 2 Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China 3 Hainan Chuntch Pharmaceutical Company Limited, Hainan Province Seaport Bonded Area 6th Workshop, Haikou 570216, China
* Authors to whom correspondence should be addressed.
Received: 5 August 2013 / Revised: 22 October 2013 / Accepted: 31 October 2013 / Published: 5 November 2013
(This article belongs to the Section Organic Synthesis)
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A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environmentally benign procedure.
Keywords: 5-arylisoxazole; without catalyst; aqueous media; synthesis 5-arylisoxazole; without catalyst; aqueous media; synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dou, G.; Xu, P.; Li, Q.; Xi, Y.; Huang, Z.; Shi, D. Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media. Molecules 2013, 18, 13645-13653.

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