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Molecules 2012, 17(7), 8010-8021; doi:10.3390/molecules17078010
Article

Gamma-Mangostin, a Micronutrient of Mangosteen Fruit, Induces Apoptosis in Human Colon Cancer Cells

1
 and 1,2,3,*
Received: 18 May 2012; in revised form: 25 June 2012 / Accepted: 27 June 2012 / Published: 3 July 2012
(This article belongs to the collection Bioactive Compounds)
Download PDF [412 KB, uploaded 18 June 2014]
Abstract: Recently colorectal cancer rates have increased rapidly in Taiwan. The treatment of colorectal cancer includes surgery, radiation therapy and chemotherapy. Mangosteen (Garcinia mangostana) is a famous Asian tropical fruit. γ-Mangostin is a xanthone derivative isolated from the fruit hull. In previous studies, we found evidence of anti-inflammatory and anti-brain tumor activities in γ-mangostin. In this study, we performed further studies to assess the apoptotic effects of γ-mangostin on colorectal adenocarcinoma cells HT29. γ-Mangostin showed concentration and time-dependent cytotoxic effects on HT29 cells. Microscopic observation under Giemsa staining showed that γ-mangostin induced cellular swelling and the appearance of apoptotic bodies, characteristic of apoptosis in HT29 cells. In addition, flow cytometry analysis showed an increase of hypodiploid cells in γ-mangostin-treated HT29 cells, while enhancement of intracellular peroxide production was detected in the same γ-mangostin-treated cells by DCHDA assay and DiOC6(3) staining. In view of the above results, γ-mangostin has demonstrated anticancer activity and induces apoptosis in HT29 colorectal adenocarcinoma cells. The evidence suggests that γ-mangostin could serve as a micronutrient for colon cancer prevention and is a potential lead compound for the development of anti-colon cancer agents.
Keywords: Garcinia mangostana; γ-mangostin; colorectal adenocarcinoma; antiproliferation; apoptosis; reactive oxygen species Garcinia mangostana; γ-mangostin; colorectal adenocarcinoma; antiproliferation; apoptosis; reactive oxygen species
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chang, H.-F.; Yang, L.-L. Gamma-Mangostin, a Micronutrient of Mangosteen Fruit, Induces Apoptosis in Human Colon Cancer Cells. Molecules 2012, 17, 8010-8021.

AMA Style

Chang H-F, Yang L-L. Gamma-Mangostin, a Micronutrient of Mangosteen Fruit, Induces Apoptosis in Human Colon Cancer Cells. Molecules. 2012; 17(7):8010-8021.

Chicago/Turabian Style

Chang, Hui-Fang; Yang, Ling-Ling. 2012. "Gamma-Mangostin, a Micronutrient of Mangosteen Fruit, Induces Apoptosis in Human Colon Cancer Cells." Molecules 17, no. 7: 8010-8021.


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