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Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of Coriandrum sativum L. Fruits
Postgraduate Program in Veterinary Sciences, State University of Ceará, 60740-000, Fortaleza, CE, Brazil
Department of Chemistry, State University of Ceará, 60740-000, Fortaleza, CE, Brazil
Centre of the Agricultural Sciences and Biological, Acaraú Valley State University, 62040-370, Sobral, CE, Brazil
Embrapa Tropical Agroindustry Center, Fortaleza, 89700-000, Ceará, Brazil
Department of the Veterinary, Faculty of Veterinary Medicine, Superior Institute of Applied Theology, 62050-100, Sobral, CE, Brazil
Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Federal University of Ceará, Fortaleza, 60441-750, Ceará, Brazil
Present address: Rua Afonso Magalhães, 629, Apto 303: Pedrinhas. CEP: 62 042-210, Sobral, Ceará, Brazil.
* Author to whom correspondence should be addressed.
Received: 15 April 2012; in revised form: 22 June 2012 / Accepted: 30 June 2012 / Published: 11 July 2012
Abstract: The aims of this study were to test the antifungal activity, toxicity and chemical composition of essential oil from C. sativum L. fruits. The essential oil, obtained by hydro-distillation, was analyzed by gas chromatography/mass spectroscopy. Linalool was the main constituent (58.22%). The oil was considered bioactive, showing an LC50 value of 23 µg/mL in the Artemia salina lethality test. The antifungal activity was evaluated against Microsporum canis and Candida spp. by the agar-well diffusion method and the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were established by the broth microdilution method. The essential oil induced growth inhibition zones of 28 ± 5.42 and 9.25 ± 0.5 for M. canis and Candida spp. respectively. The MICs and MFCs for M. canis strains ranged from 78 to 620 and 150 to 1,250 µg/mL, and the MICs and MFCs for Candida spp strains ranged from 310 to 620 and 620 to 1,250 µg/mL, respectively. C. sativum essential oil is active in vitro against M. canis and Candida spp. demonstrating good antifungal activity.
Keywords: Coriandrum sativum; essential oil; Microsporum canis; Candida spp.; Artemia salina; linalool
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Soares, B.V.; Morais, S.M.; dos Santos Fontenelle, R.O.; Queiroz, V.A.; Vila-Nova, N.S.; Pereira, C.M.C.; Brito, E.S.; Neto, M.A.S.; Brito, E.H.S.; Cavalcante, C.S.P.; Castelo-Branco, D.S.C.M.; Rocha, M.F.G. Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of Coriandrum sativum L. Fruits. Molecules 2012, 17, 8439-8448.
Soares BV, Morais SM, dos Santos Fontenelle RO, Queiroz VA, Vila-Nova NS, Pereira CMC, Brito ES, Neto MAS, Brito EHS, Cavalcante CSP, Castelo-Branco DSCM, Rocha MFG. Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of Coriandrum sativum L. Fruits. Molecules. 2012; 17(7):8439-8448.
Soares, Bruna V.; Morais, Selene M.; dos Santos Fontenelle, Raquel Oliveira; Queiroz, Vanessa A.; Vila-Nova, Nadja S.; Pereira, Christiana M. C.; Brito, Edy S.; Neto, Manoel A. S.; Brito, Erika H. S.; Cavalcante, Carolina S. P.; Castelo-Branco, Débora S. C. M.; Rocha, Marcos F. G. 2012. "Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of Coriandrum sativum L. Fruits." Molecules 17, no. 7: 8439-8448.