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Molecules 2012, 17(7), 8001-8009; doi:10.3390/molecules17078001

Pharmacological Evaluation of LiuWei Zhuanggu Granules in Rats

Department of Orthopaedic Surgery, Shanghai Fengxian Central Hospital, No. 9588, NanFeng Road, Fengxian District, Shanghai 201400, China
* Author to whom correspondence should be addressed.
Received: 4 June 2012 / Revised: 20 June 2012 / Accepted: 20 June 2012 / Published: 3 July 2012
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Many commonly consumed foods, herbs and spices contain a complex array of naturally occurring bioactive molecules called phytochemicals, which may confer health benefits. In this study, the impact of LiuWei Zhuanggu Granules (LWZGG) on mineral metabolism in osteopenia development was evaluated. Results showed that serum estrogen, bone gla protein (BGP), and calcitonin (CT) levels, bone Ca, Zn and Cu levels, femur, lumbar vertebrae and trabecular bone density, tibia maximum stress and maximum bending strength were increased, and serum parathyroid hormone (PTH), serum and urine Ca, Zn and Cu levels were decreased in rat bone. It can be concluded that LWZGG is useful to improve bone quality in ovariectomized (OVX) rats.
Keywords: LWZGG; Ca; Zn, Cu; CT; BGP; uterine LWZGG; Ca; Zn, Cu; CT; BGP; uterine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhu, H.; Ding, L.; Xiao, H.; Ni, W.; Xue, F.; He, Z. Pharmacological Evaluation of LiuWei Zhuanggu Granules in Rats. Molecules 2012, 17, 8001-8009.

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